Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a single antibiotic dose before hip replacement be just as effective as multiple doses?

NCT ID NCT05530551

Completed Disease control Sponsor: Soren Overgaard Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This trial investigates whether a single dose of antibiotics before hip replacement surgery prevents joint infections as effectively as multiple doses. The study involves about 20,000 adults with osteoarthritis undergoing hip replacement at hospitals across Denmark. Researchers will compare infection rates between the two antibiotic strategies to see if one dose is enough.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
antibiotics (cloxacillin, dicloxacillin, cefuroxime, or clindamycin)
What this could lead to
If one dose works as well as multiple doses, it could simplify infection prevention for hip replacement patients and reduce antibiotic use.
What could go wrong
This is a large trial, but results may not apply to other surgeries or patient groups. There is always a risk of infection regardless of antibiotic strategy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for OSTEOARTHRITIS, HIP are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, hip periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, HIP PROSTHETIC JOINT INFECTION TOTAL HIP ARTHROPLASTY

Contacts and locations

Locations

  • Acure Private Hospital

    Kongens Lyngby, 2800, Denmark

  • Adeas Private Hospital, Parken

    Copenhagen Ø, 2100, Denmark

  • Aleris Private Hospital, Aarhus

    Aarhus, 8200, Denmark

  • Aleris Private Hospital, Ringsted

    Ringsted, 4100, Denmark

  • Aleris Private Hospital, Søborg

    Søborg, 2860, Denmark

  • CPH Private Hospital

    Farum, 3520, Denmark

  • Capio Private Hospital, Aalborg

    Aalborg, 9000, Denmark

  • Capio Private Hospital, Aarhus

    Aarhus C, 8000, Denmark

  • Capio Private Hospital, Gildhøj

    Brøndby, 2605, Denmark

  • Capio Private Hospital, Hellerup and Odense

    Hellerup, 2900/5000, Denmark

  • Center for Planned Surgery, Silkeborg Regional Hospital

    Silkeborg, 8600, Denmark

  • Deaprtment of Orthopaedic Surgery, Aarhus University Hospital

    Aarhus, 8200, Denmark

  • Deparmtent of Orthopedic Sugery, Viborg Regional Hospital

    Viborg, 8800, Denmark

  • Deparmtent of Orthopedic Surgery, Randers Regional Hospital

    Randers, 8930, Denmark

  • Department for Planned Orthopaedic Surgery, Næstved, Copenhagen University Hospital - Næstved, Slagelse and Ringsted

    Næstved, 4700, Denmark

  • Department of Orthopaedic Surgery, Gentofte, Copenhagen University Hospital - Herlev and Gentofte

    Hellerup, 2900, Denmark

  • Department of Orthopaedic Surgery, Herlev, Copenhagen University Hospital - Herlev and Gentofte

    Herlev, 2730, Denmark

  • Department of Orthopedic Surgery and Traumatology, Bispebjerg, Copenhagen University Hospital - Bispebjerg and Frederiksberg

    Copenhagen NV, 2400, Denmark

  • Department of Orthopedic Surgery and Traumatology, Odense University Hospital and Svendborg Hospital

    Odense, 5000/5700, Denmark

  • Department of Orthopedic Surgery, Aalborg, Aalborg University Hospital

    Aalborg, 9000, Denmark

  • Department of Orthopedic Surgery, Copenahegn University Hospital - Nykøbing F

    Nykøbing Falster, 4800, Denmark

  • Department of Orthopedic Surgery, Copenhagen University Hospital - Holbæk

    Holbæk, 4300, Denmark

  • Department of Orthopedic Surgery, Esbjerg, Hospital of South West Jutland

    Esbjerg, 6700, Denmark

  • Department of Orthopedic Surgery, Farsø, Aalborg University Hospital

    Farsø, 9640, Denmark

  • Department of Orthopedic Surgery, Frederikshavn, Aalborg University Hospital

    Frederikshavn, 9900, Denmark

  • Department of Orthopedic Surgery, Grindsted, Hospital of South West Jutland

    Grindsted, 7200, Denmark

  • Department of Orthopedic Surgery, Gødstrup Regional Hospital

    Herning, 7400, Denmark

  • Department of Orthopedic Surgery, Hillerød, Copenhagen University Hospital - North Zealand

    Hillerød, 3400, Denmark

  • Department of Orthopedic Surgery, Horsens Regional Hospital, Denmark

    Horsens, 8700, Denmark

  • Department of Orthopedic Surgery, Hospital of Southern Jutland, Aabenraa and Sønderborg

    Aabenraa, 6200/6400, Denmark

  • Department of Orthopedic Surgery, Hvidovre, Copenhagen University Hospital - Amager and Hvidovre

    Hvidovre, 2650, Denmark

  • Department of Orthopedic Surgery, Zealand University Hospital, Køge

    Køge, 4600, Denmark

  • Department of Orthopedics, Lillebaelt Hospital, Vejle

    Vejle, 7100, Denmark

  • Department of Surgery, Copenhagen University Hospital - Bornholm

    Rønne, 3700, Denmark

  • Kollund Private Hospital, Kollund

    Kruså, 6340, Denmark

  • Mølholm Private Hospital, Vejle

    Vejle, 7100, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.