New antibiotic flush could beat stubborn joint infections
NCT ID NCT04662632
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a device that delivers antibiotics directly to an infected hip or knee joint for 7 days after replacement surgery. 76 adults with joint infections were randomly assigned to get either the local antibiotic irrigation plus standard care, or standard care alone. The goal was to see if the new approach improves success rates at 90 days and beyond, including survival and infection control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vancomycin hydrochloride and tobramycin sulfate
What this could lead to
If successful, this could offer a more effective way to treat joint infections after replacement surgery, potentially reducing the need for long-term antibiotics.
What could go wrong
This is a small Phase 2 trial with only 76 participants, so results may not apply to everyone. The treatment involves surgery and local antibiotics, which carry risks like allergic reactions or kidney problems.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic
Weston, Florida, 33331, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Columbia
New York, New York, 10032, United States
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Covenant Medical Center
Saginaw, Michigan, 48602, United States
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Harbor-UCLA Medical Center
Torrance, California, 90502, United States
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Integris Southwest Medical Center
Oklahoma City, Oklahoma, 73103, United States
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New York University
New York, New York, 10003, United States
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Ohio State University
Columbus, Ohio, 43202, United States
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OrthoCarolina Research Institute, Inc
Charlotte, North Carolina, 28207, United States
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Rothman Orthopaedic Institute
Philadelphia, Pennsylvania, 19107, United States
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Texas Health Presbyterian
Plano, Texas, 75093, United States
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UVA Orthopedics Center
Charlottesville, Virginia, 22903, United States
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University of Arizona, Phoenix
Phoenix, Arizona, 85004, United States
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University of Florida
Gainesville, Florida, 32611, United States
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University of Kentucky
Lexington, Kentucky, 40506, United States
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University of Utah
Salt Lake City, Utah, 84108, United States
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VA Medical Center
Washington D.C., District of Columbia, 20422, United States