New antibiotic flush shows promise for fighting joint infections after replacement surgery
NCT ID NCT04662632
First seen Apr 25, 2026 · Last updated Apr 29, 2026 · Updated 1 time
Summary
This study tested a new method of delivering antibiotics directly into the joint during a two-stage hip or knee replacement surgery for people with an infected artificial joint. The treatment, called VT-X7, alternates rinses of two antibiotics (vancomycin and tobramycin) over 7 days. Researchers compared this approach to standard care in 76 patients to see if it improved overall success—meaning the new joint stayed in place, the infection cleared, and no further surgery was needed within 90 days.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cleveland Clinic
Weston, Florida, 33331, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Columbia
New York, New York, 10032, United States
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Covenant Medical Center
Saginaw, Michigan, 48602, United States
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Harbor-UCLA Medical Center
Torrance, California, 90502, United States
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Integris Southwest Medical Center
Oklahoma City, Oklahoma, 73103, United States
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New York University
New York, New York, 10003, United States
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Ohio State University
Columbus, Ohio, 43202, United States
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OrthoCarolina Research Institute, Inc
Charlotte, North Carolina, 28207, United States
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Rothman Orthopaedic Institute
Philadelphia, Pennsylvania, 19107, United States
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Texas Health Presbyterian
Plano, Texas, 75093, United States
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UVA Orthopedics Center
Charlottesville, Virginia, 22903, United States
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University of Arizona, Phoenix
Phoenix, Arizona, 85004, United States
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University of Florida
Gainesville, Florida, 32611, United States
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University of Kentucky
Lexington, Kentucky, 40506, United States
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University of Utah
Salt Lake City, Utah, 84108, United States
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VA Medical Center
Washington D.C., District of Columbia, 20422, United States
Conditions
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