New antibiotic flush could beat stubborn joint infections

NCT ID NCT04662632

Completed Disease control Sponsor: Osteal Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a device that delivers antibiotics directly to an infected hip or knee joint for 7 days after replacement surgery. 76 adults with joint infections were randomly assigned to get either the local antibiotic irrigation plus standard care, or standard care alone. The goal was to see if the new approach improves success rates at 90 days and beyond, including survival and infection control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vancomycin hydrochloride and tobramycin sulfate
What this could lead to: If successful, this could offer a more effective way to treat joint infections after replacement surgery, potentially reducing the need for long-term antibiotics.
What could go wrong: This is a small Phase 2 trial with only 76 participants, so results may not apply to everyone. The treatment involves surgery and local antibiotics, which carry risks like allergic reactions or kidney problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periprosthetic joint infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTHETIC-JOINT INFECTION

Contacts and locations

Locations

Cleveland Clinic

Weston, Florida, 33331, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Columbia

New York, New York, 10032, United States
Covenant Medical Center

Saginaw, Michigan, 48602, United States
Harbor-UCLA Medical Center

Torrance, California, 90502, United States
Integris Southwest Medical Center

Oklahoma City, Oklahoma, 73103, United States
New York University

New York, New York, 10003, United States
Ohio State University

Columbus, Ohio, 43202, United States
OrthoCarolina Research Institute, Inc

Charlotte, North Carolina, 28207, United States
Rothman Orthopaedic Institute

Philadelphia, Pennsylvania, 19107, United States
Texas Health Presbyterian

Plano, Texas, 75093, United States
UVA Orthopedics Center

Charlottesville, Virginia, 22903, United States
University of Arizona, Phoenix

Phoenix, Arizona, 85004, United States
University of Florida

Gainesville, Florida, 32611, United States
University of Kentucky

Lexington, Kentucky, 40506, United States
University of Utah

Salt Lake City, Utah, 84108, United States
VA Medical Center

Washington D.C., District of Columbia, 20422, United States

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