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Antibiotic-Infused bone graft could slash infection risk in hip replacements

NCT ID NCT05169229

Recruiting now Disease control Sponsor: University Hospital, Linkoeping Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This trial investigates whether adding antibiotics (vancomycin and tobramycin) to bone graft material during hip replacement surgery can reduce the risk of serious joint infections. The study includes adults undergoing hip replacement who need bone graft, comparing those who receive antibiotic-impregnated graft to those who get a placebo. The main goal is to see if this approach lowers the number of reoperations due to infection within two years after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Vancomycin and Tobramycin (antibiotics) mixed into bone graft
What this could lead to
If effective, this approach could lower the risk of serious infections after hip replacement, especially in complex revision surgeries, potentially reducing the need for additional operations.
What could go wrong
This is a Phase 2 trial, so results are still preliminary. The antibiotics may not reduce infection rates as hoped, and there is a risk of allergic reactions or antibiotic resistance.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, hip periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIBIOTIC RESISTANT INFECTION ARTHROPLASTY, REPLACEMENT, HIP OSTEOARTHRITIS, HIP PROSTHETIC JOINT INFECTION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Universitetssjukhuset Linköping

    RECRUITING

    Linköping, Region Östergotland, 58185, Sweden

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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