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Antibiotic-Infused bone graft could slash infection risk in hip replacements

NCT ID NCT05169229

Disease control Sponsor: University Hospital, Linkoeping Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This trial investigates whether adding antibiotics (vancomycin and tobramycin) to bone graft material during hip replacement surgery can reduce the risk of serious joint infections. The study includes adults undergoing hip replacement who need bone graft, comparing those who receive antibiotic-impregnated graft to those who get a placebo. The main goal is to see if this approach lowers the number of reoperations due to infection within two years after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vancomycin and Tobramycin (antibiotics) mixed into bone graft
What this could lead to
If effective, this approach could lower the risk of serious infections after hip replacement, especially in complex revision surgeries, potentially reducing the need for additional operations.
What could go wrong
This is a Phase 2 trial, so results are still preliminary. The antibiotics may not reduce infection rates as hoped, and there is a risk of allergic reactions or antibiotic resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 1,100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2022

Expected to finish

Dec 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years 2. Hip arthroplasty requiring bone graft 3. Willing to provide informed consent. 4. For women of childbearing potential; a negative pregnancy test prior to surgery. Exclusion Criteria: 1. Ongoing prosthetic joint infection 2. Known allergies and contraindications for the use of vancomycin or tobramycin 3. Mental inability, reluctance, or language difficulties that according to investigator judgement, result in difficulty understanding the meaning of study participation 4. Expected difficulties to complete 2-year follow-up 5. Females of child bearing potential not using contraception 6. Pregnant females 7. Nursing females

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Conditions

The condition(s) this trial relates to.

osteoarthritis, hip periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antibiotic resistant infection Arthroplasty, replacement, hip Osteoarthritis hip Prosthetic joint infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Universitetssjukhuset Linköping

    RECRUITING

    Linköping, Region Östergotland, 58185, Sweden

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