New combo injection could ease knee pain without surgery

NCT ID NCT06685120

Recruiting now Symptom relief Sponsor: Istituto Ortopedico Rizzoli Source: ClinicalTrials.gov ↗

First seen Dec 04, 2025 · Last updated May 22, 2026 · Updated 19 times

Summary

This study tests whether combining two types of injections—platelet-rich plasma (PRP) and hyaluronic acid—works better than either alone for knee osteoarthritis. About 288 adults aged 40-75 with knee pain will receive one of three treatments and be monitored for changes in pain, stiffness, and daily function. The goal is to find a more effective way to manage symptoms without surgery.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

IRCCS Istituto Ortopedico Rizzoli
NOT_YET_RECRUITING

Bologna, 40136, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••
Istituto Ortopedico Rizzoli
RECRUITING

Bologna, 40136, Italy

Contact Email: •••••@•••••

Contact Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

OSTEO ARTHRITIS KNEE OSTEO ARTHRITIS KNEE