10,000 knee pain patients enrolled in massive treatment registry
NCT ID NCT05495334
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This registry will follow 10,000 people receiving various pain treatments for knee osteoarthritis, such as injections, nerve blocks, or knee replacement. Researchers will track pain levels, function, sleep, and side effects over time. The goal is to learn which approaches work best in everyday medical practice.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this registry could help doctors understand which pain treatments work best for knee osteoarthritis in real-world settings.
- What could go wrong
- This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by patient differences and treatment choices.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Blue Nine Systems
TERMINATEDAsheville, North Carolina, 28801, United States
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Campbell Clinic
RECRUITINGGermantown, Tennessee, 38138, United States
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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Florida Orthopaedic Associates
RECRUITINGDeLand, Florida, 32720, United States
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Genesee Orthopedics and Plastic Surgery (St. Elizabeth Med Center/ Apex Surgical Center)
COMPLETEDNew Hartford, New York, 13413, United States
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Henry M Jackson Foundation for the Advancement of Military Medicine/Walter Reed National Military Medical Center
TERMINATEDBethesda, Maryland, 20889, United States
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Jersey City Medical Center
TERMINATEDJersey City, New Jersey, 07302, United States
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Louisiana State University /Ochsner
RECRUITINGNew Orleans, Louisiana, 70112, United States
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MidState Orthopedics and Sports Medicine
RECRUITINGAlexandria, Louisiana, 71301, United States
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Northwell Health
RECRUITINGGarden City, New York, 11530, United States
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Oklahoma Surgical Hospital
RECRUITINGTulsa, Oklahoma, 74137, United States
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OrthoNebraska Clinics
RECRUITINGOmaha, Nebraska, 68144, United States
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Orthopaedic Surgical Associates
RECRUITINGNorth Chelmsford, Massachusetts, 01863, United States
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Orthopedic Education and Research Institute of So Ca (Hoag)
RECRUITINGIrvine, California, 92618, United States
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Penn Highlands DuBois
RECRUITINGDuBois, Pennsylvania, 15824, United States
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Sinai Hospital of Baltimore
RECRUITINGBaltimore, Maryland, 21215, United States
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The MORE Foundation
RECRUITINGPhoenix, Arizona, 85023, United States
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University Orthopedics Center
RECRUITINGState College, Pennsylvania, 16801, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84108, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Low-Carb diet ease knee pain? a study investigates racial differences
- Blocking knee blood vessels may offer new pain relief for severe osteoarthritis
- Which knee implant lasts longer? a Head-to-Head test
- Can cutting carbs curb knee pain? a diet trial puts it to the test
- Can virtual reality make knee pain therapy more engaging?
- Can a stem cell shot rebuild Worn-Out knees?