Knee surgery recovery boost? collagen supplement under study

NCT ID NCT05823727

Recruiting now Knowledge-focused Sponsor: University of Arkansas Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking a collagen peptide supplement before and after total knee replacement surgery can improve tissue healing, strength, and recovery. Researchers will measure changes in knee ligaments, bone density, and wound healing in 44 adults aged 50-75. Participants receive either collagen or a placebo for 24 weeks, with tissue samples collected during surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bovine collagen peptide supplement
What this could lead to: If it works, this could point toward a simple dietary supplement to improve recovery after knee replacement surgery.
What could go wrong: This is a small, early-stage study with only 44 participants, so results may not apply to everyone. The supplement may show no benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72201, United States

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