Could ozone be the key to easing knee arthritis pain?

NCT ID NCT07678996

Recruiting now Symptom relief Sponsor: Kayseri City Hospital Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests whether injecting ozone gas into the knee joint, combined with exercise, can reduce pain and improve function in people aged 40-75 with moderate knee osteoarthritis. Participants receive three weekly ozone injections at different concentrations (10, 15, or 20 µg/mL) plus a home exercise program, or exercise alone. The goal is to find the most effective dose for symptom relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ozone
What this could lead to: If effective, ozone injections could offer a non-surgical option to reduce pain and improve mobility in people with knee osteoarthritis.
What could go wrong: This is a small, early-stage trial with 80 participants, so results may not apply widely. Ozone injections may cause discomfort or infection, and the benefit over exercise alone is unproven.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

Kayseri City Hospital
RECRUITING

Kayseri, 38080, Turkey (Türkiye)

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