Freeze or zap? new trial tests Drug-Free pain relief for stubborn knee arthritis
NCT ID NCT07664371
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two minimally invasive procedures—cryoneurolysis (freezing nerves) and radiofrequency (using electric pulses)—to relieve knee pain in adults with osteoarthritis who haven't responded to standard treatments like painkillers or physical therapy. Sixty participants will be randomly assigned to one of the two procedures, and their pain levels will be measured using a standard pain scale. The goal is to see which method provides better, drug-free pain relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cryoneurolysis (nerve freezing) and radiofrequency (nerve heating via electric pulses)
What this could lead to
If successful, this could offer a drug-free, long-lasting pain relief option for people with knee osteoarthritis who have not found relief from pills or physical therapy.
What could go wrong
This is a small, early-stage trial with only 60 participants, so results may not apply to everyone. The procedures are not permanent and pain may return over time.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Faculty of medicine, Tanta University
RECRUITINGTanta, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••