New pain shot may cut opioid use after knee replacement
NCT ID NCT07216586
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two pain relief methods after total knee replacement: a long-acting pain shot (Zynrelef) given directly into the knee during surgery versus a standard nerve block. The goal is to see which method better reduces the need for opioid painkillers in the first 72 hours after surgery. About 120 adults having knee replacement will take part.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Miami
Miami, Florida, 33125, United States
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