One surgery or two? knee replacement study aims to settle debate

NCT ID NCT03564730

Ongoing Knowledge-focused Sponsor: Orthopaedic Innovation Centre Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares having both knees replaced at the same time versus one after the other in people with knee osteoarthritis. About 224 participants will be randomly assigned to one approach. Researchers will track recovery, joint function, and quality of life to help guide patient and surgeon decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help surgeons and patients decide whether to replace both knees at once or separately, improving recovery planning.
What could go wrong: This is an observational comparison of procedures, not a test of a new treatment. Results may not apply to all patients, and individual risks vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

Concordia Hospital

Winnipeg, Manitoba, R2K 3S8, Canada
Kingston Health Sciences Center - KGH

Kingston, Ontario, K7L 2V7, Canada
London Health Sciences Centre

London, Ontario, N6A 5W9, Canada
McGill University

Montreal, Quebec, H3A 0G4, Canada
Ottawa Hospital Research Institute

Ottawa, Ontario, K1H 8L6, Canada
St. Joseph's - McMaster University

Hamilton, Ontario, L8N 4A6, Canada
St. Michael's Hospital

Toronto, Ontario, M5B 1W8, Canada
University of Calgary

Calgary, Alberta, T2P 3C5, Canada

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