Knee replacement recovery: could a steroid taper help?

NCT ID NCT06489626

Terminated Symptom relief Sponsor: F. Johannes Plate Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study planned to test whether a 6-day course of oral methylprednisolone after total knee replacement could improve pain, sleep, and knee movement. Participants would also receive a steroid injection during surgery. The study was withdrawn before enrolling anyone, so no conclusions can be drawn.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: methylprednisolone and dexamethasone
What this could lead to: If it had worked, this could point toward a simple way to improve pain control and mobility after knee replacement surgery.
What could go wrong: The study was withdrawn before any participants were enrolled, so no results are available. Steroids can affect wound healing and blood sugar, which limited who could join.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS (KNEE) KNEE OSTEOARTHRITIS PAIN, POSTOPERATIVE

Contacts and locations

Locations

UPMC East

Monroeville, Pennsylvania, 15146, United States
UPMC Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States

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