Could Low-Dose radiation be the next knee pain fix?

NCT ID NCT05562271

Completed Symptom relief Sponsor: Seoul National University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether low-dose radiation therapy can reduce pain and improve function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis received either low-dose radiation or a sham treatment. Researchers measured pain and function improvements over 4 months to see if this approach is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-dose radiation therapy
What this could lead to: If it works, this could offer a new, non-drug option for reducing knee pain and improving mobility in people with osteoarthritis.
What could go wrong: This is an early exploratory trial with only 114 participants. The benefits may be small or not last long, and radiation carries potential risks like tissue damage, though at low doses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

Samsung Medical Center

Seoul, South Korea
Seoul National University Hospital

Seoul, South Korea
Seoul National University Hospital / SMG-SNU Boramae Medical Center

Seoul, 07061, South Korea

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