UCLA tests if naltrexone cancels the Fear-Busting power of a hug
NCT ID NCT04166071
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
Researchers at UCLA are studying whether naltrexone, a drug that blocks opioid receptors, can stop reminders of a social support figure from helping people overcome fear. Sixty healthy adults aged 18-35 will receive either naltrexone or a placebo, then undergo a fear extinction procedure where threatening cues are paired with images of a loved one. The goal is to see if the drug disrupts the brain's natural safety-signal mechanism, shedding light on how social bonds protect against fear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- naltrexone
- What this could lead to
- If it works, this could reveal how social support helps reduce fear, potentially guiding future treatments for anxiety disorders.
- What could go wrong
- This is a very early, small study (60 healthy people) testing a single dose. It may not translate to real-world fear or anxiety conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UCLA
Los Angeles, California, 90095, United States
-
UCLA Department of Psychology, 5514 Pritzker Hall
Los Angeles, California, 90095-1563, United States
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