Tailored brain zaps could revolutionize depression treatment

NCT ID NCT06572683

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study explores a personalized form of brain stimulation called resonant frequency rTMS for people with major depression. Researchers will test different stimulation frequencies to see which one best engages brain circuits. The goal is to develop a more targeted treatment approach. The study involves 84 participants and uses brain imaging and EEG to measure effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Transcranial Magnetic Stimulation (TMS)

What this could lead to

If successful, this could lead to more effective, personalized brain stimulation treatments for depression.

What could go wrong

This is an early-stage study focused on measuring brain activity, not on treating depression directly. It may not lead to better outcomes for patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder endogenous depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of California

    Los Angeles, California, 90024, United States