Does cannabis work differently for men and women? new study investigates

NCT ID NCT04385082

Ongoing Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study aims to understand if cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give 160 regular cannabis users either active cannabis or a placebo and measure their pain response, drug effects, and blood levels. The goal is to gather knowledge that could lead to safer, more personalized cannabis use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cannabis (THC)
What this could lead to: If successful, this could help personalize cannabis use for pain management based on sex, potentially improving safety and effectiveness.
What could go wrong: This is an early Phase 1 study focused on understanding differences, not proving a treatment works. Results may not lead to direct medical recommendations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cannabis dependence Pain substance abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABUSE, DRUG PAIN

Contacts and locations

Locations

University of California, Los Angeles

Los Angeles, California, 90095, United States

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