Penicillin shots tested to stop syphilis in pregnancy
NCT ID NCT07189208
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving penicillin shots to pregnant women at high risk for syphilis can prevent infection. Researchers in Rio de Janeiro will enroll 500 women and compare the shots to standard care. Participants receive monthly injections and tests during their third trimester.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- benzathine penicillin
- What this could lead to
- If it works, this could provide a simple way to prevent syphilis during pregnancy, reducing the risk of passing the infection to the baby.
- What could go wrong
- This is a Phase 2 trial, so it's still early. The drug may not prevent infection as hoped, and some participants may have allergic reactions or side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centro de Referencia e Atenção Especializada a Saúde da Mulher (CRAESM)
NOT_YET_RECRUITINGDuque de Caxias, Rio de Janeiro, Brazil
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Hospital Federal dos Servidores do Estado
RECRUITINGRio de Janeiro, Rio de Janeiro, Brazil
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Policlínica Hospital Municipal Duque de Caxias
RECRUITINGDuque de Caxias, Rio de Janeiro, Brazil
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Unidade Básica de Saúde José de Freitas
NOT_YET_RECRUITINGDuque de Caxias, Rio de Janeiro, Brazil