Congenital syphilis
MONDO:0005714A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia.
Also known as: MTCT of syphilis, congenital syphilis, mother-to-child transmission of syphilis
16 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
-
Could oral antibiotics replace hospital stays for Syphilis-Exposed newborns?
Disease control Recruiting nowThis study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 9…
Phase: PHASE2 • Sponsor: London School of Hygiene and Tropical Medicine • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
-
New antibiotic cocktail aimed at Drug-Resistant infections in babies
Disease control Recruiting nowThis study tests a combination of two antibiotics, aztreonam and avibactam, in newborns and infants up to 9 months old who have serious infections caused by gram-negative bacteria. The trial has two parts: one to see how a single dose moves through the body, and another to test m…
Phase: PHASE2 • Sponsor: Pfizer • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
-
Double antibiotic attack: could a Two-Drug combo beat severe infections faster?
Disease control Recruiting nowThis study tests whether adding a second antibiotic (fosfomycin) to the standard antibiotic (ceftazidime) helps people with severe gram-negative infections recover faster. About 100 hospitalized adults will be randomly assigned to get either the combo or the standard drug plus a …
Phase: PHASE3 • Sponsor: Angela HUTTNER • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
-
Five-Minute Finger-Prick test could speed syphilis diagnosis in pregnancy
Diagnosis Recruiting nowThis study tests whether a rapid finger-prick blood test for syphilis and HIV can be used in a prenatal clinic for pregnant people at risk. The test gives results in five minutes, potentially speeding up diagnosis and treatment. Participants will provide feedback on their experie…
Phase: NA • Sponsor: McMaster University • Aim: Diagnosis
Last updated Jul 09, 2026 00:00 UTC
-
Penicillin shots tested to stop syphilis in pregnancy
Prevention Recruiting nowThis study tests whether giving penicillin shots to pregnant women at high risk for syphilis can prevent infection. Researchers in Rio de Janeiro will enroll 500 women and compare the shots to standard care. Participants receive monthly injections and tests during their third tri…
Phase: PHASE2 • Sponsor: University of California, Los Angeles • Aim: Prevention
Last updated Jun 27, 2026 13:00 UTC
-
Real-World watch: is zavicefta safe for tough infections?
Knowledge-focused Recruiting nowThis study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …
Sponsor: Pfizer • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:53 UTC