Congenital syphilis
MONDO:0005714A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia.
Also known as: MTCT of syphilis, congenital syphilis, mother-to-child transmission of syphilis
16 clinical trials for this condition and its sub-types.
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Broader categories
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New hope for newborns: simpler syphilis treatment on trial
Disease control Not yet recruitingThis study tests whether a 10-day course of oral amoxicillin works as well as a single injected dose of penicillin to treat congenital syphilis in newborns up to 30 days old. About 374 infants across 12 U.S. sites will be randomly assigned to one of the two treatments. The goal i…
Phase: PHASE4 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New 10-Minute syphilis test could save mothers and babies in uganda
Diagnosis Not yet recruitingSyphilis affects about 1 in 25 pregnant women in Uganda and can harm both mother and baby if untreated. This study will test a new rapid test that gives results in 10 minutes, comparing it to standard lab tests that take hours or days. Researchers will enroll 24 mothers and their…
Sponsor: St George's, University of London • Aim: Diagnosis
Last updated Jun 26, 2026 17:22 UTC
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New Ultrasound-Guided IV could spare newborns painful needle sticks
Symptom relief Not yet recruitingThis study compares two types of IV catheters in 104 newborns with congenital syphilis who need 10 days of antibiotics. One group gets a standard short catheter, the other a longer catheter placed using ultrasound by a specialized nurse. The goal is to see which lasts longer and …
Phase: NA • Sponsor: Hospital de Clinicas de Porto Alegre • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Are ICU patients getting the right antibiotic dose? new study aims to find out
Knowledge-focused Not yet recruitingThis study looks at whether standard antibiotic doses are effective for ICU patients on ECMO (heart-lung support) or kidney dialysis. Researchers will measure drug levels in 40 adults with serious infections. The goal is to see if dosing adjustments are needed to avoid under- or …
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC