New hope for newborns: simpler syphilis treatment on trial

NCT ID NCT07457385

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 10-day course of oral amoxicillin works as well as a single injected dose of penicillin to treat congenital syphilis in newborns up to 30 days old. About 374 infants across 12 U.S. sites will be randomly assigned to one of the two treatments. The goal is to find a simpler, effective option that may be easier for families to manage at home.

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