Could oral antibiotics replace hospital stays for Syphilis-Exposed newborns?
NCT ID NCT06921213
First seen Jun 24, 2026 · Last updated Aug 12, 2026 · Updated 3 times
Summary
This study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 90 infants and will measure drug levels in blood and spinal fluid, as well as side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Linezolid, Amoxicillin, Benzathine Penicillin G
- What this could lead to
- If successful, this could provide a simpler, outpatient treatment option for newborns at risk of congenital syphilis, reducing the need for prolonged hospitalization.
- What could go wrong
- This is an early phase 2 trial with only 90 participants, so results may not apply broadly. The antibiotics may not achieve adequate drug levels in the blood or spinal fluid, or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ASYMPTOMATIC CONGENITAL SYPHILIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Malawi Liverpool Wellcome Programme
NOT_YET_RECRUITINGBlantyre, Malawi
-
Stellenbosch
RECRUITINGStellenbosch, South Africa
-
Universitas Indonesia
RECRUITINGJakarta, Indonesia
More trials for these conditions
Other studies related to the condition(s) this trial covers.