Could oral antibiotics replace hospital stays for Syphilis-Exposed newborns?
NCT ID NCT06921213
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 90 infants and will measure drug levels in blood and spinal fluid, as well as side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Linezolid, Amoxicillin, Benzathine Penicillin G
What this could lead to
If successful, this could provide a simpler, outpatient treatment option for newborns at risk of congenital syphilis, reducing the need for prolonged hospitalization.
What could go wrong
This is an early phase 2 trial with only 90 participants, so results may not apply broadly. The antibiotics may not achieve adequate drug levels in the blood or spinal fluid, or could cause side effects.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SYPHILIS, CONGENITAL are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Malawi Liverpool Wellcome Programme
NOT_YET_RECRUITINGBlantyre, Malawi
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Stellenbosch
RECRUITINGStellenbosch, South Africa
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Universitas Indonesia
NOT_YET_RECRUITINGJakarta, Indonesia
Contact Phone: •••-•••-•••• Email: •••••@•••••