Gram-negative bacterial infections

This study tests a new mRNA vaccine designed to prevent chlamydia, a common sexually transmitted infection. About 1,560 adults aged 18 to 29 who are at higher risk of infection will receive either a low, medium, or high dose of the vaccine or a placebo. Researchers will monitor s…

This early-stage trial is testing a new vaccine that combines protection against several serious childhood diseases: diphtheria, tetanus, whooping cough, meningitis, and Hib. The study involves 260 children aged 2 months to 6 years to check the vaccine's safety and immune respons…

This study tests a new vaccine designed to protect against four types of meningococcal bacteria that can cause serious infections like meningitis and sepsis. About 1,100 healthy adults aged 19 to 55 will receive a single dose to see how well it triggers the immune system and if i…

This study tests a new IV antibiotic (aztreonam-avibactam) in hospitalized children aged 9 months to 18 years with serious gram-negative bacterial infections. About 48 participants will receive either the new drug or the best available standard treatment. The goal is to see how t…

This study is checking how safe the antibiotic sulbactam-durlobactam is for people hospitalized with a hard-to-treat bacterial infection called Acinetobacter baumannii. Researchers will watch 100 participants for about 28 days to see if they have any side effects, especially alle…

This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2…

This study tests a combination of two antibiotics, aztreonam and avibactam, in newborns and infants up to 9 months old who have serious infections caused by gram-negative bacteria. The trial has two parts: one to see how a single dose moves through the body, and another to test m…

This study is testing whether a drug called tadalafil (often used for erectile dysfunction) combined with a home cycling program can help boys with Duchenne muscular dystrophy. The drug aims to improve blood flow to muscles, which is often poor in DMD, while exercise builds stren…

This study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 9…

This study looks at whether treating a common stomach infection (H. pylori) can improve symptoms and lung function in people with COPD. Researchers will give standard antibiotic therapy to 54 H. pylori-positive COPD patients and then measure changes in their breathing tests and s…

This study tests whether adding bismuth to a 14-day course of vonoprazan and amoxicillin works better at clearing H. pylori infection than the two-drug regimen alone. About 990 adults who have not been treated before will take part. The main goal is to see which approach eradicat…

This study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well…

This study provides free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15-26 in New Orleans. Those who test positive can get treatment at no cost and are encouraged to bring their partners. The goal is to reduce STI rates and health disparities in this c…

This study is testing a 14-day treatment for Helicobacter pylori, a stomach infection that can cause ulcers and cancer. The treatment uses two drugs, vonoprazan and clarithromycin, and is guided by a stool test to check if the bacteria are resistant to clarithromycin. The goal is…

This study compares two treatments for H. pylori infection, a common stomach bug. One uses a newer drug called tegoprazan, while the other uses a standard proton pump inhibitor. The trial will enroll 400 adults in South Korea, where antibiotic resistance makes treatment difficult…

This study compares two antibiotic treatments for H. pylori, a stomach infection. 600 adults will get either a 10-day standard treatment or a 7-day treatment tailored to their bacteria's drug resistance. The goal is to see which approach eradicates the infection more effectively.

This study looks at how well a 14-day course of tegoprazan (a stomach acid reducer) combined with two antibiotics works to clear H. pylori infection. About 200 adults who need a stomach scope will take the treatment, and researchers will check if the bacteria are gone using a bre…

This study tests whether a newer acid-reducing drug (vonoprazan) works better than a standard one (esomeprazole) for clearing H. pylori, a bacteria that can cause stomach ulcers and indigestion. About 80 adults with H. pylori will take one of the two drug combinations for 14 days…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study tests whether a 14-day course of just two medications (vonoprazan and amoxicillin) works as well as the usual four-drug combination for eradicating H. pylori, a bacteria that can cause stomach ulcers and cancer. About 372 adults with a confirmed H. pylori infection who…

This study tests whether choosing antibiotics based on lab tests of the bacteria works better than standard antibiotic combinations for people whose H. pylori infection hasn't been cured before. About 450 adults will receive either a tailored or standard regimen for 14 days. The …

This study tests whether stable patients with a common blood infection (gram-negative bacteraemia) can safely switch from IV antibiotics to oral pills within 72 hours. Researchers will compare early oral therapy to continued IV treatment in 720 adults. The main goal is to see if …

This trial tests two surgical methods for repeat eyelid surgery in people with trichiasis, a condition where eyelashes rub against the eye. About 1,000 participants in Tanzania will receive either the B-RAP or BLTR procedure. The goal is to see which technique better prevents eye…

This study looks at whether treating Helicobacter pylori (Hp), a common stomach infection, can also help improve metabolic syndrome (high blood sugar, cholesterol, and weight). Researchers will give standard Hp treatment alone or with probiotics or berberine to 120 adults. They w…

This study tests whether a 7-day combination of vonoprazan, high-dose amoxicillin, and bismuth can effectively eradicate H. pylori bacteria in the stomach. About 316 adults with a first-time H. pylori infection will be randomly assigned to either the 7-day triple therapy or a sta…

This study is testing whether a powerful antibiotic called piperacillin/tazobactam can be given as a continuous shot under the skin instead of through an IV line. About 240 adults with serious bacterial infections will be randomly assigned to receive the drug either subcutaneousl…

This study is testing two different ways of giving a combination of two antibiotics (ceftazidime-avibactam and aztreonam) to treat serious infections caused by bacteria that are resistant to many drugs. The researchers want to see if giving the drugs one after the other works as …

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part,…

This study is testing an antibiotic called Sulbactam-Durlobactam in hospitalized children from birth to under 18 years old who have or may have an Acinetobacter infection. The goal is to find the right dose and check that it is safe. About 48 children will receive the drug throug…

This study tests a new way to treat H. pylori, a bacteria that can cause stomach ulcers and cancer. During an endoscopy, doctors fill the stomach with a saltwater solution that is activated by argon plasma to kill the bacteria. The trial will compare two methods of making this so…

This study tests a newer acid-blocking drug (vonoprazan) against a standard one, each combined with vitamin D or probiotics, to treat H. pylori infection. About 66 adults with confirmed H. pylori will receive one of three treatments for two weeks. The goal is to see which combina…

This study compares different antibiotic strategies for people hospitalized with Gram-negative bloodstream infections. The goal is to find which approach leads to better outcomes, like survival and fewer complications, while also reducing the risk of antibiotic resistance. About …

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study is testing the safety and how the body handles Vaborem, a combination of two antibiotics (meropenem and vaborbactam), in children from birth to under 18 years old who have serious Gram-negative bacterial infections. All 44 participants will receive the drug intravenous…

This study compares two 14-day antibiotic treatments for Helicobacter pylori infection, a common stomach bug that can cause ulcers. The triple therapy uses bismuth, amoxicillin, and vonoprazan, while the quadruple therapy adds rabeprazole, tetracycline, and metronidazole. Researc…

This study tests three different antibiotic combinations to treat a dangerous, drug-resistant bacteria called CRAB that causes infections in intensive care patients. Researchers will compare colistin combined with either fosfomycin, ampicillin/sulbactam, or eravacycline in 108 su…

This study tests three different 14-day treatments for H. pylori, a bacteria that can cause stomach ulcers and cancer. About 390 infected adults will receive either a new triple therapy with bismuth, a dual therapy, or a standard treatment. The goal is to see which works best and…

This study tests three different anti-ulcer medications (Dexlansoprazole, Lansoprazole, and Vonoprazan) combined with two antibiotics (Levofloxacin and Amoxicillin) to see which works best for eradicating H. pylori infection. About 942 adults in Pakistan with H. pylori will take …

This study tests different combinations of acid-blocking drugs (P-CABs) with bismuth and antibiotics to treat H. pylori, a stomach infection that can cause ulcers. About 1,730 adults aged 18-70 with confirmed H. pylori will receive one of several treatment regimens. Researchers w…

This study tests a micropulse laser for diabetic macular edema, a condition causing vision loss in people with diabetes. Fifty participants with initial or stubborn swelling will receive the laser treatment. Researchers will measure changes in vision and retinal thickness to see …

This study tests a 'screen and treat' approach for H. pylori infection in 14-18 year olds in Chile, where stomach cancer rates are high. Researchers will screen up to 1000 teens and randomly assign 210 persistently infected participants to receive antibiotics or no treatment. The…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study tests a new two-drug combination (keverprazan and amoxicillin) to treat H. pylori, a stomach infection that can cause ulcers and cancer. About 477 adults will receive different doses and treatment lengths (10 or 14 days) to find the best balance of effectiveness, fewer…

This study tests whether adding a probiotic called Saccharomyces boulardii to a standard antibiotic cocktail helps clear Helicobacter pylori infections that didn't respond to earlier treatments. About 1,248 adults who have failed prior H. pylori therapy will be randomly assigned …

This study tests whether adding bismuth to standard antibiotics works better than antibiotics alone to clear H. pylori infection and heal peptic ulcers in 80 children. Participants take a 14-day treatment, then continue acid-reducing medication for a few more weeks. Researchers w…

This study tests two different 14-day treatments for Helicobacter pylori, a bacteria that can cause stomach ulcers. About 240 adults with confirmed infection will take either tegoprazan or vonoprazan, both combined with amoxicillin. The goal is to see if the newer tegoprazan comb…

This trial tests two strategies to control sexually transmitted infections (STIs) among 2,900 cisgender men who have sex with men in Kenya. One group gets a single dose of antibiotics every few months (WHO-recommended periodic presumptive treatment), another takes doxycycline wit…

This study tests whether adding doxycycline to the standard penicillin shot works better for treating early syphilis in people with HIV. About 688 adults will be randomly assigned to get either penicillin alone or penicillin plus a week of doxycycline pills. The main goal is to s…

This study tests whether adding a second antibiotic (fosfomycin) to the standard antibiotic (ceftazidime) helps people with severe gram-negative infections recover faster. About 100 hospitalized adults will be randomly assigned to get either the combo or the standard drug plus a …

This study looks at 2,600 heart attack patients who had a stent placed and also have an H. pylori infection. Half will get a 2-week course of vonoprazan plus amoxicillin to treat the infection, while the other half gets a standard 6-month acid blocker (pantoprazole). The goal is …

This Phase 2 trial tests whether a dietary supplement called Carminal can help heal the stomach lining and reduce symptoms in people with H. pylori gastritis. Eighty adults will receive either Carminal or a placebo alongside standard antibiotic therapy, followed by 12 weeks of co…

This study compares two types of acid-reducing drugs—vonoprazan (a newer drug) and rabeprazole (a standard drug)—when used as part of a 10-day combination therapy for H. pylori infection. About 320 adults with confirmed H. pylori will be randomly assigned to one of the two treatm…

This study tests a new device called the esophageal string test (EST) to diagnose H. pylori, a stomach bacteria that can cause ulcers and cancer. Participants swallow a capsule with a string inside that collects stomach fluids. Researchers compare the results to standard tests. T…

This study tests whether artificial intelligence (AI) can help doctors better detect H. pylori infection and precancerous stomach changes during routine endoscopy. The goal is to see if AI assistance can reduce deaths from stomach cancer. The trial will enroll 6,000 adults aged 2…

This study aims to increase syphilis testing and treatment for pregnant women who haven't had prenatal care or a syphilis test during their pregnancy. Researchers will offer rapid point-of-care tests in the emergency department and obstetrical triage, then help connect those who …

This study is testing a new rapid diagnostic device called TruPlex that can detect HIV, Hepatitis B, and Syphilis from a small blood sample. Researchers will enroll 1000 adults at risk for these infections to see how accurate and easy the test is to use in clinics and point-of-ca…

This study is testing a new, non-invasive stool test that looks for specific gene changes in H. pylori bacteria linked to stomach cancer. Researchers will compare the test's accuracy with a standard risk questionnaire in 15,000 adults aged 40 and older. The goal is to see if this…

This study is testing two new blood test kits designed to diagnose syphilis. Researchers will collect blood samples from 1000 people, including those with symptoms, those at high risk, and healthy controls. The goal is to see how accurate these new kits are compared to standard l…

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study tests a new device called MagIA H3S that can screen for HIV, hepatitis B, hepatitis C, and syphilis using a single blood sample. Researchers will enroll about 2,950 people in Ivory Coast and Kenya to see how accurate the device is compared to standard lab tests. If it …

This study checks if a new self-test for HIV and syphilis is accurate and easy for people to use at home. About 900 adults in Canada will try the test and compare results to lab tests. The study also looks at how peer support can help homeless people in Toronto get tested and tre…

This study aims to see if a simple stool test can accurately detect Helicobacter pylori infection in children, avoiding the need for an invasive endoscopy under anesthesia. Researchers will compare the stool test results with standard biopsy results in 188 children aged 16 or you…

This study is testing a new rapid test for syphilis that uses a fingerstick blood sample, giving results quickly at the clinic. Researchers want to see if this quick test is as accurate as the standard lab test. About 1,300 people visiting the Ottawa Sexual Health Clinic who need…

This study is testing two new molecular tests (qPCR and TMA) to detect syphilis in pregnant women and their newborns. Researchers will compare these tests to current CDC guidelines to see if they are more accurate. The goal is to improve diagnosis and prevent congenital syphilis,…

This study will test whether screening pregnant women for chlamydia and gonorrhea can reduce the risk of preterm birth. About 2,000 women in Botswana will be randomly assigned to receive either standard care or additional STI testing early in pregnancy and again in the third trim…

This study is looking at whether it's safe and effective to give the Tdap vaccine (for whooping cough) and the RSV vaccine at the same doctor's visit during pregnancy, or if they should be given separately. The researchers will recruit 60 healthy pregnant individuals and randomly…

This study in Botswana tests whether offering sexually transmitted infection (STI) testing alongside HIV prevention medication (PrEP) helps more pregnant women start and continue using PrEP. About 600 pregnant women without HIV will be split into two groups: one gets standard car…

This study tests whether giving penicillin shots to pregnant women at high risk for syphilis can prevent infection. Researchers in Rio de Janeiro will enroll 500 women and compare the shots to standard care. Participants receive monthly injections and tests during their third tri…

This study tests a new pill called TP-05 (lotilaner) to see if it can prevent Lyme disease in healthy adults who are often around ticks. The pill is already used in pets to kill ticks. Researchers will give either a low dose, high dose, or placebo to 700 volunteers and watch for …

This study tests whether taking the antibiotic doxycycline can prevent bacterial sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in adolescent and young adult females. About 760 participants aged 13-29 who have had an STI in the past year and recent…

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study tests a program called Shamba Maisha that provides farming tools, training, and school gardens to families in Kenya. The goal is to reduce food insecurity and poverty, which are linked to higher STI and HIV risk in adolescent girls. Researchers will follow 900 girls an…

This study tests whether taking the antibiotic doxycycline shortly after sex can prevent bacterial STIs like syphilis, gonorrhea, and chlamydia. It involves 200 men, transgender women, and travestis in Rio de Janeiro who are at higher risk. Participants choose whether to use doxy…

This study tests whether taking a single 200 mg dose of doxycycline within 24–72 hours after unprotected sex can prevent gonorrhea, chlamydia, and syphilis in men who have sex with men. Researchers in Bangkok will enroll 400 participants and follow them for 12 weeks. If effective…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study aims to see if using a blood marker called Cystatin C can better predict how antibiotics work in critically ill ICU patients with drug-resistant infections. Researchers will compare Cystatin C to standard kidney function tests and a dye-based gold-standard test. The go…

This study tests whether a rapid lab test can help doctors choose the right antibiotic sooner for patients with bloodstream infections. About 400 adults with positive blood cultures will be randomly assigned to either the rapid test or standard testing. The goal is to see if the …

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This observational study is looking at how two antibiotics, ceftazidime/avibactam and fosfomycin, work in the body to treat infections caused by carbapenem-resistant Enterobacterales (CRE), a type of superbug. Researchers will monitor 60 adult patients to see if the drug levels i…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study looks at whether taking common acid-reducing drugs (proton pump inhibitors, or PPIs) affects the accuracy of a stool DNA test for H. pylori, a stomach bacteria. Researchers will test 25 adults who need PPIs, first while on the drug and then after stopping it for 4 week…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study is observing 200 hospitalized adults with carbapenem-resistant Acinetobacter baumannii (CRAB) infections—a type of superbug—who are treated with the antibiotic sulbactam-durlobactam. Researchers will compare their outcomes to patients receiving other treatments to see …

This study looks at whether urine samples can show immune markers of chlamydia infection in women. Participants provide urine, vaginal, and blood samples to compare immune responses. The goal is to find easier ways to study chlamydia immunity, which could help develop better test…

This study tests whether offering rapid point-of-care testing for gonorrhea and chlamydia helps more teens get HIV testing and PrEP. About 6,460 adolescents aged 16-24 will be compared: some get rapid testing, others get standard lab testing. The goal is to see if same-day result…

This study tests whether a web-based educational program can improve pregnant women's knowledge about influenza and Tdap vaccines and increase their intention to get vaccinated. Researchers will compare the program to standard antenatal care in 351 pregnant women in Malaysia. Par…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study aims to understand how syphilis bacteria spread from people without visible symptoms, focusing on women and men who have sex with women only—groups often overlooked in past research. Researchers will collect swabs and blood samples from 480 participants with early syph…

This registry will follow 10,000 people in Shandong, China, who are being treated for H. pylori infection. Doctors will prescribe standard treatments based on guidelines, and researchers will track how well each treatment works and any side effects. The goal is to learn which str…

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study looks at how common Helicobacter pylori infection is in people newly diagnosed with stomach cancer in Martinique. Researchers will collect tumor samples, healthy tissue, and blood to build a biobank. The goal is to understand why stomach cancer is more common in the We…

This study looks at how two antibiotics, ceftriaxone and benzathine penicillin G, are processed by the body during pregnancy. Up to 78 pregnant women in the U.S. will take one of these drugs as part of their regular care, and researchers will measure drug levels in their blood. T…

This early-stage study is testing whether a single dose of an experimental antibiotic combination (sulopenem etzadroxil plus probenecid) is safe and tolerable in 12 adolescents already receiving standard antibiotics for a bacterial infection. Researchers will measure how the drug…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at how the antibiotic cefiderocol behaves in the bodies of people with severe burns. Researchers want to find the best dose to kill bacteria and prevent resistance. The study will enroll 12 adults with burns who have good kidney function.

This study looks at how common Helicobacter pylori (a stomach germ linked to cancer) is in adults without stomach symptoms who are already getting a screening colonoscopy. About 1,000 participants will also have a stomach exam (gastroscopy) during the same visit, with small tissu…

This study compares two strong antibiotics, polymyxin B and colistin, in treating serious infections caused by bacteria that are resistant to many common drugs. Researchers will look at medical records of 480 adults with pneumonia or bloodstream infections to see which antibiotic…

This study follows 3,000 adults aged 40 and older who carry Helicobacter pylori, a common stomach bug. Researchers want to see if people with certain high-risk subtypes of the bacteria develop stomach cancer more often than those with other subtypes or no infection. Participants …

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study looks at whether blood cancer patients with a serious infection can safely stop antibiotics sooner if they are stable for 72 hours, instead of the usual 10-day course. About 172 adults will be randomly assigned to either a personalized short course or standard long cou…

This study looks at over 500,000 patient records to see if diagnostic codes in electronic health records accurately identify chlamydia infections. Researchers will compare these codes with lab test results. The goal is to improve how real-world data is used for chlamydia research…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study collects information from about 100 adults in Alsace who have had a confirmed case of human anaplasmosis, a bacterial infection spread by ticks. Researchers want to learn more about how common it is, what symptoms people have, and how serious it can be. The goal is to …

This study follows 600 people at higher risk for stomach cancer to track precancerous changes in the stomach lining. Researchers collect tissue, blood, and saliva samples during routine endoscopies. The goal is to understand why some people's stomach changes progress to cancer wh…

This study aims to create a safe, controlled human infection model for whooping cough. Healthy adults aged 18-50 will receive a nasal dose of the bacteria to cause a mild infection. Researchers will monitor symptoms and test nasal samples to find the best dose that infects most p…

This study looks at how the H. pylori bacterium is distributed in different stages of stomach inflammation and early gastric cancer. Researchers will examine tissue samples from 231 people using a special staining technique to see where and how much bacteria are present. The goal…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …