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Could a common ED drug and cycling help kids with duchenne?

NCT ID NCT06290713

Recruiting now Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a drug called tadalafil (often used for erectile dysfunction) combined with a home cycling program can help boys with Duchenne muscular dystrophy. The drug aims to improve blood flow to muscles, which is often poor in DMD, while exercise builds strength and endurance. About 50 ambulatory boys aged 6 and older will take either tadalafil or a placebo daily for 6 months and do weekly cycling sessions. The goal is to see if this combo can improve muscle function and fatigue resistance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Tadalafil (a drug that widens blood vessels) and a home-based cycling exercise program
What this could lead to
If successful, this could point toward a new way to improve muscle function and slow disease progression in Duchenne muscular dystrophy by combining a common blood-flow drug with exercise.
What could go wrong
This is a small, early-phase trial with only 50 participants, so results may not apply to everyone. The drug and exercise may not improve muscle function as hoped, and there are risks like side effects from tadalafil or injury from exercise.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Aneurysm Duchenne muscular dystrophy Motor Activity muscular dystrophy tabes dorsalis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DMD DUCHENNE DISEASE DUCHENNE MUSCULAR DYSTROPHY EXERCISE MUSCULAR DYSTROPHY MUSCULAR DYSTROPHY IN CHILDREN VASODILATION

Contacts and locations

Locations

  • University of Florida Clinical and Translational Research Building

    RECRUITING

    Gainesville, Florida, 32603, United States

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