MUSCULAR DYSTROPHY

This study tests a brain implant called BrainGate2 for people with tetraplegia (paralysis of all four limbs) due to spinal cord injury, ALS, stroke, or similar conditions. The goal is to see if it is safe and if participants can use their thoughts to control a computer cursor or …

This study tests a single dose of a gene therapy called AB-1003 in 10 adults with a rare genetic muscle disease (LGMD2I/R9) that causes progressive weakness. The main goal is to check safety, not yet to prove it works. Participants must be able to walk 10 meters in under 30 secon…

This study tests a powered knee-ankle-foot orthosis (KAFO) called Nomad in 36 people who have trouble walking due to conditions like stroke, spinal cord injury, or multiple sclerosis. Participants will use the device at home for three months to see if it improves mobility, balanc…

This study tests whether taking amino acid supplements, combined with a special diet and exercise program, can help people with facioscapulohumeral muscular dystrophy (FSHD) gain muscle, lose fat, and improve physical abilities like walking and strength. Researchers will compare …

This study tests a robotic leg brace (exoskeleton) designed to improve walking in children aged 3 to 17 with conditions like cerebral palsy, spina bifida, muscular dystrophy, or incomplete spinal cord injury. The device can assist or resist leg movement during walking. The trial …

This registry aims to connect people diagnosed with myotonic dystrophy or facioscapulohumeral muscular dystrophy, along with their family members, with researchers studying these inherited muscle-weakening diseases. By joining, participants help scientists better understand the c…

This study tests a portable digital device that analyzes walking without markers, comparing it to standard motion-capture systems. It includes 30 adults (ages 18-65) with certain neuromuscular diseases or healthy volunteers. The goal is to see if this simpler tool can reliably me…

This study aims to improve how doctors observe nerves and muscles using ultrasound, a safe imaging technique. Researchers will collect normal measurements from healthy adults and compare them to people with neuromuscular disorders like muscular dystrophy or peripheral neuropathy.…

This study aims to find the genes and mutations that cause inherited heart conditions like cardiomyopathy and arrhythmia, as well as muscular dystrophy. Researchers will collect DNA samples from patients and their families, focusing on those with multiple affected relatives. The …

This study looks at people with inherited neurological disorders to learn how these diseases develop and change over time. Researchers will collect medical history, do physical exams, and take blood or skin samples for genetic testing. Up to 3,500 children and adults with these r…