Can a lower steroid dose preserve strength in young boys with DMD?

NCT ID NCT05412394

Recruiting now Disease control Sponsor: Anne M. Connolly Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial is testing whether a lower weekly dose of the corticosteroid prednisolone (5 mg/kg per week) can be as effective as the standard higher dose (10 mg/kg per week) in preserving motor function in young boys with Duchenne muscular dystrophy (DMD). The study will enroll boys aged 1 to 30 months who have a confirmed DMD diagnosis and have not yet been treated with glucocorticosteroids. Over 24 months, researchers will measure changes in gross motor skills, as well as language, social, and fine motor development, to see if the lower dose offers a better balance of benefit and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: prednisolone (a corticosteroid)
What this could lead to: If effective, a lower weekly dose of prednisolone could offer a safer, equally effective treatment option for young boys with Duchenne muscular dystrophy, potentially reducing side effects.
What could go wrong: This is a small, early-phase trial, and the lower dose may not be as effective as the standard dose. Corticosteroids can have significant side effects, especially in young children.

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Conditions

The condition(s) this trial relates to.

Duchenne muscular dystrophy muscular dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DUCHENNE MUSCULAR DYSTROPHY

Contacts and locations

Locations

Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45220, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75235, United States

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