Cure My Disease

Don't miss your cure!

 Log in / Sign up

New antibiotic combo vaborem tested in kids for tough infections

NCT ID NCT06828848

Recruiting now Disease control Sponsor: Menarini Group Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study is testing the safety and how the body handles Vaborem, a combination of two antibiotics (meropenem and vaborbactam), in children from birth to under 18 years old who have serious Gram-negative bacterial infections. All 44 participants will receive the drug intravenously every 8 hours for up to 14 days. The goal is to find the right dose and ensure it is safe for children.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Vaborem (meropenem plus vaborbactam)
What this could lead to
If this trial works, it could provide a safe and effective antibiotic option for children with serious bacterial infections that are hard to treat.
What could go wrong
This is a small, early-phase study with only 44 children, so results may not apply to all kids. The drug may cause side effects or not work as well as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE PYELONEPHRITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute pyelonephritis gram-negative bacterial infections nosocomial infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAM NEGATIVE INFECTIONS

Contacts and locations

Locations

  • Azienda Ospedaliero-Universitaria di Parma

    RECRUITING

    Parma, Italy

  • CHRU de Tours Hôpital Clocheville Clinical Research Site

    TERMINATED

    Tours, France

  • Faculty Hospital Kralovske Vinohrady, Paediatric Clinic

    TERMINATED

    Prague, Czechia

  • Fakultni nemocnice Ostrava

    TERMINATED

    Ostrava, Czechia

  • Giannina Gaslini Institute

    TERMINATED

    Genoa, Italy

  • Hospital Armand Trousseau Clinical Research Site

    TERMINATED

    Paris, France

  • Hospital Clinico Universitario de Santiago de Compostela

    TERMINATED

    Santiago de Compostela, Spain

  • Hospital Dr Josep Trueta

    RECRUITING

    Girona, Spain

  • Hospital General Universitario Gregorio Marañón

    RECRUITING

    Madrid, Spain

  • Hospital Regional Universitario de Málaga

    TERMINATED

    Málaga, Spain

  • Hospital Sant Joan de Deu

    RECRUITING

    Barcelona, Spain

  • Hospital Universitario Puerta del Mar

    RECRUITING

    Cadiz, Spain

  • Hôpital Robert Debré

    RECRUITING

    Paris, France

  • Hôpital mère-enfant - CHU de Nantes

    RECRUITING

    Nantes, France

  • Insytut Centrum Zdrowia Matki Polki / Polish Mother´s Memorial Hospital Research Institute (ICZMP)

    TERMINATED

    Lodz, Poland

  • Nice University Hospital (CHU de Nice)

    RECRUITING

    Nice, France

  • Ospedale Pediatrico Bambino Gesù

    RECRUITING

    Rome, Italy

  • Ospedale Regina Margherita

    RECRUITING

    Torino, Italy

  • Ospedale Sant'Orsola

    RECRUITING

    Bologna, Italy

  • Policlinico di Bari

    RECRUITING

    Bari, Italy

  • Uniwersyteckie Centrum Kliniczne WUM

    RECRUITING

    Warsaw, Poland

  • Wojskowy Instytut Medyczny - Państwowy Instytut Badawczy

    RECRUITING

    Warsaw, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.