Could adding a common antibiotic beat syphilis in HIV patients?

NCT ID NCT06069141

Recruiting now Disease control Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study tests whether adding doxycycline to the standard penicillin shot works better for treating early syphilis in people with HIV. About 688 adults will be randomly assigned to get either penicillin alone or penicillin plus a week of doxycycline pills. The main goal is to see if the combination leads to a faster drop in syphilis blood test levels at 24 and 48 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Benzathine penicillin G and doxycycline
What this could lead to: If successful, this could lead to a more effective treatment regimen for early syphilis in people living with HIV, reducing relapse and transmission.
What could go wrong: This is a relatively small, early-stage study. The added benefit of doxycycline may be modest, and side effects or antibiotic resistance could limit its use.

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Conditions

The condition(s) this trial relates to.

latent early syphilis primary syphilis syphilis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY SYPHILIS, LATENT, SEROLOGICAL RELAPSE AFTER TREATMENT

Contacts and locations

Locations

Chi Mei Medical Hospital
RECRUITING

Tainan, Taiwan
Far Eastern Memorial Hospital
RECRUITING

Taipei, Taiwan, 110, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, Taiwan
Kaohsiung Veterans General Hospital
RECRUITING

Kaohsiung City, Taiwan
National Cheng-Kung University Hospital
RECRUITING

Tainan, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, Taiwan, 110, Taiwan
National Taiwan University Hospital Hsin-Chu Branch
RECRUITING

Hsinchu, Taiwan, 110, Taiwan
Taipei Vetetrans General Hospital
RECRUITING

Taipei, Taiwan, 110, Taiwan
Taoyuan General Hospital
RECRUITING

Taoyuan, Taiwan, 110, Taiwan

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