Could adding a common antibiotic beat syphilis in HIV patients?
NCT ID NCT06069141
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding doxycycline to the standard penicillin shot works better for treating early syphilis in people with HIV. About 688 adults will be randomly assigned to get either penicillin alone or penicillin plus a week of doxycycline pills. The main goal is to see if the combination leads to a faster drop in syphilis blood test levels at 24 and 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Benzathine penicillin G and doxycycline
What this could lead to
If successful, this could lead to a more effective treatment regimen for early syphilis in people living with HIV, reducing relapse and transmission.
What could go wrong
This is a relatively small, early-stage study. The added benefit of doxycycline may be modest, and side effects or antibiotic resistance could limit its use.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Chi Mei Medical Hospital
RECRUITINGTainan, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Far Eastern Memorial Hospital
RECRUITINGTaipei, Taiwan, 110, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITINGKaohsiung City, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kaohsiung Veterans General Hospital
RECRUITINGKaohsiung City, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Cheng-Kung University Hospital
RECRUITINGTainan, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Taiwan University Hospital
RECRUITINGTaipei, Taiwan, 110, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Taiwan University Hospital Hsin-Chu Branch
RECRUITINGHsinchu, Taiwan, 110, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taipei Vetetrans General Hospital
RECRUITINGTaipei, Taiwan, 110, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taoyuan General Hospital
RECRUITINGTaoyuan, Taiwan, 110, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••