New syphilis combo treatment tested in HIV patients – trial cut short
NCT ID NCT05980871
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at two different antibiotic combinations for treating early syphilis in people living with HIV. One group received a single shot of ceftriaxone plus a week of doxycycline pills, while the other got the standard single shot of penicillin plus the same doxycycline course. The goal was to see if the ceftriaxone combo worked as well, while also treating common co-infections like gonorrhea and chlamydia. The trial was terminated early, so the full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ceftriaxone plus doxycycline, compared to benzathine penicillin G plus doxycycline
- What this could lead to
- If successful, this could show that a single shot of ceftriaxone plus a week of doxycycline works as well as the standard penicillin shot plus doxycycline for treating early syphilis in people with HIV, while also covering other sexually transmitted infections.
- What could go wrong
- The trial was terminated early, so results may be incomplete. It is a Phase 4 study with only 109 participants, and findings may not apply to people without HIV or those with later-stage syphilis.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Kuan-Yin Lin
Taipei, Taiwan, 110, Taiwan
More trials for these conditions
Other studies related to the condition(s) this trial covers.