Could a simple antibiotic pill replace the gold standard shot for syphilis?

NCT ID NCT04838717

First seen Nov 20, 2025 · Last updated May 15, 2026 · Updated 23 times

Summary

This study tested whether taking doxycycline pills for 14 days works as well as a single penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal was to see if the pill option is a safe and effective alternative, especially when penicillin is in short supply.

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Contacts and locations

Locations

  • CHRU Jean Minjoz

    Besançon, 25000, France

  • CHU Toulouse - Hôpital de la Grave - GeGIDD

    Toulouse, 34000, France

  • Hôpital Henri Mondor

    Créteil, 94000, France

  • Hôpital Hotel Dieu

    Paris, 75001, France

  • Hôpital Saint Louis - GeGIDD

    Paris, 75009, France

  • Hôpital Saint Louis - SMIT

    Paris, 75009, France

  • Hôpital de la Croix Rousse

    Lyon, 69000, France

Conditions

Explore the condition pages connected to this study.