Hidden syphilis: new study targets silent spread in women and straight men

NCT ID NCT07300254

Recruiting now Knowledge-focused Sponsor: Monash University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand how syphilis bacteria spread from people without visible symptoms, focusing on women and men who have sex with women only—groups often overlooked in past research. Researchers will collect swabs and blood samples from 480 participants with early syphilis to check if live bacteria are present in the mouth, anus, vagina, or urine. The goal is to find out if asymptomatic transmission is possible, which could help improve prevention efforts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could clarify how syphilis spreads without symptoms, potentially improving prevention strategies for understudied groups.
What could go wrong: This is an observational study, not a treatment trial. It may not directly change clinical practice, and findings may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

primary syphilis syphilis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYPHILIS

Contacts and locations

Locations

Burrell Street Clinic, Guy's and St Thomas'
RECRUITING

London, SE10UN, United Kingdom
Foundation for Professional Development
NOT_YET_RECRUITING

Pretoria, 0184, South Africa
Jefferiss Clinic St Mary's Hospital, Imperial College London
RECRUITING

London, W21DL, United Kingdom
London School of Hygiene & Tropical Medicine
ACTIVE_NOT_RECRUITING

London, WC1E7HT, United Kingdom
Monash University
ACTIVE_NOT_RECRUITING

Melbourne, Victoria, 3004, Australia
Mortimer Market Centre
RECRUITING

London, WC1E6JB, United Kingdom
National Institute for Communicable Diseases
NOT_YET_RECRUITING

Johannesburg, 2192, South Africa
Shanghai Skin Disease Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200443, China
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200082, China

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