Which Anti-Ulcer drug works best for h. pylori? large trial aims to find out
NCT ID NCT07344506
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests three different anti-ulcer medications (Dexlansoprazole, Lansoprazole, and Vonoprazan) combined with two antibiotics (Levofloxacin and Amoxicillin) to see which works best for eradicating H. pylori infection. About 942 adults in Pakistan with H. pylori will take one of the three combinations for 14 days. The main goal is to see which treatment clears the infection most effectively, measured by a breath test four weeks after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexlansoprazole, Lansoprazole, or Vonoprazan combined with Levofloxacin and Amoxicillin
What this could lead to
If successful, this could identify the most effective anti-ulcer drug combination for eradicating H. pylori in regions with high antibiotic resistance, potentially reducing stomach cancer risk.
What could go wrong
This is a phase 4 trial in a specific population (Pakistan), so results may not apply elsewhere. Antibiotic resistance could still limit effectiveness, and side effects from the drugs are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sindh Institute of Advanced Endoscopy and Gastroenterology (SIAG), DUHS
RECRUITINGKarachi, 75600, Pakistan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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