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Which Anti-Ulcer drug works best for h. pylori? large trial aims to find out

NCT ID NCT07344506

Recruiting now Disease control Sponsor: Dow University of Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests three different anti-ulcer medications (Dexlansoprazole, Lansoprazole, and Vonoprazan) combined with two antibiotics (Levofloxacin and Amoxicillin) to see which works best for eradicating H. pylori infection. About 942 adults in Pakistan with H. pylori will take one of the three combinations for 14 days. The main goal is to see which treatment clears the infection most effectively, measured by a breath test four weeks after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Dexlansoprazole, Lansoprazole, or Vonoprazan combined with Levofloxacin and Amoxicillin
What this could lead to
If successful, this could identify the most effective anti-ulcer drug combination for eradicating H. pylori in regions with high antibiotic resistance, potentially reducing stomach cancer risk.
What could go wrong
This is a phase 4 trial in a specific population (Pakistan), so results may not apply elsewhere. Antibiotic resistance could still limit effectiveness, and side effects from the drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Helicobacter pylori infectious disease peptic ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

H. PYLORI GASTROINTESTINAL DISEASE H.PYLORI ERADICATION RATE H.PYLORI INFECTION

Contacts and locations

Locations

  • Sindh Institute of Advanced Endoscopy and Gastroenterology (SIAG), DUHS

    RECRUITING

    Karachi, 75600, Pakistan

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