Gram-negative bacterial infections

This study tests a new vaccine called TdaP2gen in 320 pregnant women in Thailand to see if it safely protects their babies from tetanus, diphtheria, and whooping cough. The vaccine is given during pregnancy, and researchers measure antibody levels in mothers and infants up to 18 …

This early-stage trial is testing a new combination vaccine that protects against whooping cough, diphtheria, and tetanus (Tdap) in people aged 10 and older. Researchers want to see if different doses are safe and trigger an immune response. The study involves 96 volunteers and c…

This study tests a new version of the Tdap vaccine (which protects against tetanus, diphtheria, and whooping cough) that has reduced antigens. The goal is to see if it is safe and triggers a strong immune response in people aged 6 and up. Around 660 volunteers will receive either…

This study tests whether a simpler two-drug treatment (vonoprazan plus one antibiotic) works as well as a three-drug treatment (vonoprazan plus two antibiotics) for H. pylori infection. About 150 adults with confirmed H. pylori will take either regimen for 14 days. The main goal …

This early-phase trial will test a combination of a Chinese herbal formula (Yiqi Huoxue Jiedu) and bacteriophages (viruses that target bacteria) in 250 people with severe pneumonia caused by drug-resistant bacteria. The goal is to see if this combo can clear the infection faster …

This Phase 3 trial tests whether a new acid-reducing drug, anaprazole, works better than the standard drug esomeprazole when used with bismuth and two antibiotics to treat H. pylori infection. About 556 adults in China will take either anaprazole or esomeprazole pills twice daily…

This study tests a single booster dose of a combined vaccine against diphtheria, tetanus, and whooping cough (dTpa) in 85 healthy Japanese adolescents aged 11 to 13. Researchers will check if the shot triggers a strong immune response and monitor for side effects one month after …

This study compares two 14-day treatments for H. pylori, a stomach bacteria that can cause ulcers and cancer. About 90 adults will receive either a levofloxacin-based sequential therapy or a bismuth-based quadruple therapy. The goal is to see which treatment works better and has …

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…

This study tests a new way to treat Helicobacter pylori (H. pylori) infections that didn't get better with the first round of antibiotics. Instead of using a scope to take a stomach sample, doctors will use a stool test to find which antibiotics will work best. About 531 adults w…

This study compares a personalized treatment plan for H. pylori infection against the usual standard care in 360 veterans. The personalized approach uses genetic testing and antibiotic sensitivity to choose the best drugs. The goal is to see which method cures more infections wit…

This study tests whether adding melatonin to the strong antibiotic colistin helps patients with multidrug-resistant bacterial infections. These infections are hard to treat and often deadly. The trial will give 70 adults either melatonin or a placebo alongside their regular treat…

This study tests whether a 10-day course of oral amoxicillin works as well as a single injected dose of penicillin to treat congenital syphilis in newborns up to 30 days old. About 374 infants across 12 U.S. sites will be randomly assigned to one of the two treatments. The goal i…

This study tests a new antibiotic combination (BV100 plus other drugs) against hard-to-treat infections like pneumonia and bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii. About 120 adults in the hospital will receive either the new combo or the best…

This study tests whether a 7-day course of antibiotics chosen by a stool test works as well as a 14-day course for people with stubborn H. pylori infections. About 290 adults who have failed previous treatment will get a stool test to find which drugs their infection resists, the…

This study tests whether a 7-day course of antibiotics, chosen based on a stool test, can clear H. pylori infection as effectively as a standard 14-day course. About 544 adults with a first-time H. pylori infection will provide a stool sample for drug-resistance testing and then …

This study compares a 7-day high-dose vonoprazan-amoxicillin treatment to a standard 14-day regimen for eradicating H. pylori, a common stomach bacteria linked to ulcers and cancer. About 290 adults with confirmed infection will be randomly assigned to one of the two groups. The …

This early-phase trial tests a Chinese herbal formula (Yiqi Huoxue Jiedu) combined with bacteriophages—viruses that target specific bacteria—in 240 people with severe pneumonia caused by drug-resistant germs. The goal is to see if the combination clears the infection faster and l…

This phase 3 trial will test how well two different triple therapies—one using a standard acid reducer (proton pump inhibitor) and one using a newer drug (vonoprazan)—work to eliminate H. pylori infection. It will also see if adding zinc improves results. The study plans to enrol…

This study will test whether standard treatment to eliminate H. pylori bacteria can improve ongoing stomach and gut symptoms in 100 adults. Participants will receive antibiotics and acid-reducing medication, and their symptoms will be tracked using a questionnaire. The goal is to…

This early-stage study tests whether adding specially-made viruses (phages) to standard antibiotics can safely treat stubborn lung infections in adults with cystic fibrosis. About 30 participants will receive a 7-day course of both treatments. The main goal is to check safety, bu…

This study tests two ways of taking amoxicillin with tegoprazan to treat H. pylori, a stomach infection that can cause ulcers. About 240 adults will take the same total daily dose of antibiotics, but one group takes it three times a day and the other twice a day. The goal is to s…

This study tests whether adding a traditional Chinese medicine formula, Feireqing Granules, to standard care can improve survival in people with severe pneumonia caused by multidrug-resistant Gram-negative bacteria. The trial will enroll 152 adults and measure death rates at 14 a…

This study tests whether adding a traditional Chinese medicine granule (Huazhi Rougan) to standard antibiotics can better treat both H. pylori infection and metabolic-associated fatty liver disease (MASH). About 286 adults with both conditions will receive either the herbal granu…

This study will test a new rapid device called TruPlex that checks for HIV, Hepatitis B, and Syphilis using a single fingerstick blood sample. About 500 adults at risk for these infections will take part. Researchers want to see if the test is accurate and easy for trained staff …

This study will test whether a fast, point-of-care test for chlamydia and gonorrhea can reduce the time it takes for people to start antibiotics. Four hundred asymptomatic adults visiting a sexual health clinic will be randomly assigned to receive either the rapid test or a stand…

This study will test a rapid fingerstick test for HIV and syphilis in pregnant women who come to the emergency department without prior prenatal care. Researchers want to see if offering this test leads to more women being diagnosed and starting treatment right away. The goal is …

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study looks at whether offering a rapid syphilis test during family planning visits (for birth control or abortion) is practical and acceptable to patients. About 70 participants will get a fingerstick test with results in 10-15 minutes, instead of waiting days. The goal is …

This study will check if a new device called MagIA H3S can accurately detect HIV, hepatitis B, hepatitis C, and syphilis in pregnant women in the Democratic Republic of the Congo. About 7,500 pregnant women will take part. The goal is to see if this quick test works as well as st…

Syphilis affects about 1 in 25 pregnant women in Uganda and can harm both mother and baby if untreated. This study will test a new rapid test that gives results in 10 minutes, comparing it to standard lab tests that take hours or days. Researchers will enroll 24 mothers and their…

This phase 3 trial will give a single dose of the dTpa vaccine (Boostrix) to 95 healthy Japanese pregnant women between 27 and 37 weeks of pregnancy. The goal is to see if the vaccine triggers strong immunity in the mothers and passes protective antibodies to their babies at birt…

This study compares two types of IV catheters in 104 newborns with congenital syphilis who need 10 days of antibiotics. One group gets a standard short catheter, the other a longer catheter placed using ultrasound by a specialized nurse. The goal is to see which lasts longer and …

This study tests whether medications that calm mast cells (ketotifen and cromolyn) can safely reduce persistent symptoms like fatigue, pain, and brain fog in people who had a tick-borne illness. Fifty adults aged 21-65 will receive either one of these drugs or a standard antihist…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This study tests whether a safe dose of ivermectin, a common deworming drug, can make human feces deadly to flies that spread trachoma. Trachoma is a leading cause of blindness, and these flies carry the bacteria from person to person. Twelve healthy adults will take ivermectin, …

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study tests whether training healthcare providers to reduce stigma can increase the use of HIV and STI prevention services, like testing and preventive medications. It will involve 8 clinics in the Mississippi Delta and track changes in how often patients receive these servi…

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This early-stage study will give a single dose of the experimental antibiotic gepotidacin to 20 hospitalized children aged 2 to 12 who are already receiving standard antibiotics for a bacterial infection or as a preventive measure. Researchers will measure how the drug moves thro…

This study looks at how satisfied young people and those with low incomes are with free HIV and STI testing and counselling in Lucerne and Zurich. Around 1,800 participants will fill out a questionnaire after their visit. The goal is to see if these free services meet people's ne…

This study looks at a simpler way to detect resistance to colistin, a last-resort antibiotic, in multidrug-resistant bacteria. Researchers will collect 90 samples from hospitalized patients and compare a disk test to the standard method. They will also check for resistance genes …

This study looks at whether combining a blood test for H. pylori bacteria with a painless stomach ultrasound can predict serious complications from peptic ulcers, like bleeding or a hole in the stomach. Researchers will study 230 adults with stomach symptoms to see if these non-i…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at whether a rapid fingerstick test that gives results in 10-20 minutes can help more people get screened for HIV, hepatitis C, and syphilis during mobile clinic visits. About 200 patients of the WVU Street Medicine team can choose the rapid test, a traditional b…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study aims to understand how the environment, the bacteria that cause melioidosis, and the human body interact to cause disease. Researchers will follow about 1,000 infected patients and 1,000 healthy matched controls in Thailand, Laos, and Cambodia for one year. They will a…

This study will look at 130 people with H. pylori-related gastritis to see if the infection is linked to anxiety, depression, or other psychological symptoms. Researchers will also check whether treating the infection improves mental health. The goal is to better understand the c…

This pilot study will check if simethicone, a medicine used to reduce gas during endoscopy, makes it harder to detect H. pylori bacteria. About 100 adults with a positive H. pylori test will take simethicone or a placebo before their procedure. The goal is to see if the drug lowe…

This study will measure two molecules, called miRNA-155 and miRNA-204, in stomach tissue from 100 children with ongoing belly pain. The goal is to see if these molecules are linked to gastritis (stomach inflammation) and infection with H. pylori bacteria. Researchers will use spe…

This study tests whether point-of-care STI tests, which give results in about 10 minutes, can speed up treatment for pregnant women compared to standard lab tests. About 756 pregnant women at Grady Memorial Hospital will either get the rapid tests or standard testing. The goal is…

This study will check how common Helicobacter pylori infection is in 100 adults with inflammatory bowel disease (Crohn's or colitis) at the Guadeloupe hospital. Researchers will take extra stomach biopsies during routine endoscopy to study the stomach's bacteria. The goal is to s…

This study looks at whether standard antibiotic doses are effective for ICU patients on ECMO (heart-lung support) or kidney dialysis. Researchers will measure drug levels in 40 adults with serious infections. The goal is to see if dosing adjustments are needed to avoid under- or …

This study will survey 300 general practitioners in Upper Egypt to evaluate their knowledge, attitudes, and practices regarding Helicobacter pylori infection. Researchers aim to identify common barriers that prevent proper diagnosis and treatment. The goal is to highlight gaps th…

This study will test a new way to care for people in Ghana who have both a neglected tropical skin disease (like leprosy or Buruli ulcer) and mental health challenges like depression or anxiety. Researchers will work with 200 affected adults and local health workers to create a G…

This study tests a new rapid diagnostic system that can tell doctors which antibiotic will work against a blood infection in 4-6 hours, instead of the usual 18-24 hours. Researchers want to see if this faster information helps ICU doctors change to a better antibiotic sooner. The…

This observational study will check if having an H. pylori stomach infection is linked to more active lupus in 115 adults. Researchers will use a stool test to detect the bacteria and a standard lupus score to measure disease activity. No treatments are given; the goal is simply …