Simpler h. pylori treatment could reduce antibiotic use
NCT ID NCT07624422
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a simpler two-drug treatment (vonoprazan plus one antibiotic) works as well as a three-drug treatment (vonoprazan plus two antibiotics) for H. pylori infection. About 150 adults with confirmed H. pylori will take either regimen for 14 days. The main goal is to see how many people are cured of the infection, while also tracking side effects and how well patients follow the treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vonoprazan (a stomach acid reducer) combined with antibiotics (amoxicillin, levofloxacin, tinidazole)
What this could lead to
If successful, this could show that a simpler, two-drug regimen is as effective as a three-drug regimen for treating H. pylori, potentially reducing side effects and antibiotic resistance.
What could go wrong
This is a small, early-stage trial (phase 4) with only 150 participants. The results may not apply to everyone, and the simpler regimen might not work as well in real-world settings.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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General Assembly of Damascus Hospital
Damascus, Syria