Can customizing antibiotics beat stomach bug resistance?

NCT ID NCT05250050

Terminated Disease control Sponsor: Shanghai Zhongshan Hospital Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This trial compares three ways to treat Helicobacter pylori, a common stomach infection that can lead to ulcers or cancer. One approach uses genetic testing to pick antibiotics, another uses traditional sensitivity testing, and the third uses a standard fixed combination. The goal is to see which method eradicates the infection most effectively and is most cost-efficient. Adults aged 18-75 with confirmed H. pylori infection may participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A combination of antibiotics and acid-reducing drugs (esomeprazole, bismuth, metronidazole, clarithromycin, levofloxacin, amoxicillin, tetracycline) chosen based on susceptibility testing or standard care.
What this could lead to: If successful, this could show that tailoring antibiotics to the specific H. pylori strain improves cure rates and reduces healthcare costs.
What could go wrong: The trial is early and may not show a clear benefit over standard treatment. Antibiotic resistance and side effects could also limit effectiveness.

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Conditions

The condition(s) this trial relates to.

Helicobacter pylori infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HELICOBACTER PYLORI INFECTION

Contacts and locations

Locations

Huashan Hospital, Fudan University

Shanghai, Shanghai Municipality, 200040, China
Renji Hospital, School of Medicine, Shanghai Jiaotong University

Shanghai, Shanghai Municipality, 200000, China
Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, 200032, China

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