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Can probiotics make h. pylori antibiotics easier on the gut?

NCT ID NCT07827170

Disease control Sponsor: Anabio R&D Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers test whether Bacillus probiotics, given alongside standard four-drug antibiotics for H. pylori infection, reduce gut side effects and improve treatment tolerance. The trial enrolls 336 adults with H. pylori who receive either a single-strain probiotic, a multi-strain probiotic, or a placebo during 14 days of antibiotics. Over 8 weeks, the team tracks adverse events, gastrointestinal symptoms, stool consistency, and whether the infection is cleared.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bacillus probiotic supplements (LiveSpo CLAUSY and LiveSpo DIA30)
What this could lead to
If the probiotics help, doctors could add them to standard H. pylori treatment to ease antibiotic side effects and help patients finish the full course.
What could go wrong
Probiotics may not reduce side effects or improve cure rates, and the trial cannot show whether any benefit lasts. Some people may still get diarrhea or other gut problems during antibiotic treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 336 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 to 65 years; * Diagnosed with H. pylori infection by the 13C-urea breath test or the rapid urease test; * Indicated for H. pylori eradication treatment with the four-drug bismuth regimen (BQT); * Agree to participate in the study and have been informed and signed the consent form Exclusion Criteria: * Active bleeding gastric or duodenal ulcer. * Use of antibiotics, acid-suppressing drugs (PPIs, H2RAs), non-steroidal anti-inflammatory drugs (NSAIDs), laxatives, antidiarrheals, or probiotics (excluding yogurt) within at least 4 weeks before participating in the study, except for laxatives used as part of the study's endoscopic preparation procedure. * Chronic inflammatory bowel disease (IBD), acute intestinal infection, gastrointestinal cancer (stomach cancer, colon cancer), acute or chronic pancreatitis, immunosuppression (including prolonged corticosteroid use), or psychiatric disorders. * Alcohol abuse, history of delirium tremens, or alcoholic liver disease. * Pregnant or breastfeeding women.

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Conditions

The condition(s) this trial relates to.

Helicobacter pylori infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antibiotic-associated adverse events Gastrointestinal dysbiosis Helicobacter pylori infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Tam Anh Ha Noi General Hospital

    Hanoi, Vietnam

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