Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a common seed oil boost stomach infection treatment?

NCT ID NCT05957432

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers test whether adding black seed oil to a vonoprazan-based triple therapy clears Helicobacter pylori infection better than the standard triple therapy alone. The trial enrolls 90 adults with confirmed H. pylori who have not been treated before. Participants receive either the combination or the standard therapy, and researchers measure infection clearance, markers of inflammation and oxidative stress, stomach symptoms, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
black seed oil added to vonoprazan-based triple therapy
What this could lead to
If it works, adding black seed oil could offer a way to improve H. pylori clearance and reduce stomach symptoms with fewer side effects.
What could go wrong
This is a small Phase 2 trial, so results may not hold in larger groups. Black seed oil can cause stomach upset, and the triple therapy carries risks of nausea, diarrhea, and allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2023

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female patients * Age 18 to 75 years old * Patients with confirmed H. pylori infection by stool Ag test who had not received prior eradication therapy Exclusion Criteria: * History of hypersensitivity / allergy to any of the study drugs i.e., Esomeprazole, vonoprazan, penicillin, or clarithromycin * History of previous H. pylori eradication therapy * History of using PPIs, antibiotics that affect H. pylori within 4 weeks * History of gastric malignancy or surgery * Serious cardiovascular, pulmonary, renal, hepatic disorders or active malignancy * Pregnancy or breast feeding * History of drug abuse or active alcohol abuse

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Helicobacter pylori infection are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Helicobacter pylori infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Helicobacter pylori infection

Contacts and locations

Locations

  • GIT department zagazig university hospital

    Zagazig, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.