New Low-Dose tdap vaccine trial aims to boost protection with fewer side effects
NCT ID NCT07418372
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new version of the Tdap vaccine (which protects against tetanus, diphtheria, and whooping cough) that has reduced antigens. The goal is to see if it is safe and triggers a strong immune response in people aged 6 and up. Around 660 volunteers will receive either the low-dose or high-dose experimental vaccine, or a standard vaccine for comparison. Researchers will monitor for side effects and measure antibody levels 30 days after vaccination.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Reduced-antigen tetanus, diphtheria, and acellular pertussis vaccine
- What this could lead to
- If successful, this could provide a safer booster option for older children and adults to protect against tetanus, diphtheria, and whooping cough.
- What could go wrong
- This is an early-phase trial (I/II) with only 660 participants, so results may not confirm broad effectiveness or safety. Side effects like injection-site reactions or fever are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Jiangjin District Center for Disease Control and Prevention
Chongqing, Chongqing Municipality, China
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