Could a 7-Day antibiotic course replace 3 weeks for silent STI?
NCT ID NCT07767422
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This trial tests whether a 7-day course of doxycycline can effectively cure asymptomatic anal lymphogranuloma venereum (LGV), a sexually transmitted infection caused by Chlamydia trachomatis. Currently, treatment lasts 21 days, but recent studies suggest a shorter course may work. The study will enroll 120 men with asymptomatic anal LGV, give them doxycycline 200 mg daily for 7 days, and check for microbiological cure four weeks later.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- doxycycline
- What this could lead to
- If successful, this could shorten treatment for asymptomatic anal LGV from 21 days to 7 days, simplifying care and reducing antibiotic use.
- What could go wrong
- The trial is small and early-stage, and the shorter course may not fully clear the infection in all cases, potentially leading to treatment failure or reinfection.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Hospitalier de Tourcoing, Ceggid
Tourcoing, 59208, France
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Centre Hospitalier de Tourcoing, Service Des Maladies Infectieuses Et Tropicales
Tourcoing, 59208, France
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Chu Toulouse Purpan, Service Des Maladies Infectieuses Et Tropicales
Toulouse, 31059, France
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Chu de Nantes, Maladies Infectieuses (Cpmit)
Nantes, 44093, France
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Hopital Bichat - Claude Bernard, Ceggid
Paris, 75018, France
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Hopital Bichat - Claude Bernard, Service Des Maladies Infectieuses Et Tropicales
Paris, 75018, France
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Hopital François Mitterrand, Centres Gratuits D'Information, de Depistage Et de Diagnostic (Ceggid)
Dijon, 21079, France
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Hopital Intercommunal Andre Gregoire - Ght , Centres Gratuits D'Information, de Depistage Et de Diagnostic (Ceggid)
Montreuil, 93100, France
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Hopital La Pite Salpetriere, Service Des Maladies Infectieuses Et Tropicales
Paris, 75013, France
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Hopital Saint-Louis, Service Des Maladies Infectieuses Et Tropicales
Paris, France
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Hospices Civils de Lyon, Centres Gratuits D'Information, de Depistage Et de Diagnostic (Ceggid)
Lyon, 69004, France
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Hotel-Dieu, Service Des Maladies Infectieuses Et Tropicales
Paris, 75004, France
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Service de Prevention Aupres Des Jeunes, Ceggid
Marseille, 13331, France
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University Hospital, Bordeaux, Department of Infectious Diseases
Bordeaux, 33000, France