Could a Two-Drug cocktail beat the standard Four-Drug regimen for stomach bug?

NCT ID NCT07179159

Recruiting now Disease control Sponsor: Yanqing Li Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a 14-day course of just two medications (vonoprazan and amoxicillin) works as well as the usual four-drug combination for eradicating H. pylori, a bacteria that can cause stomach ulcers and cancer. About 372 adults with a confirmed H. pylori infection who have never been treated before will be randomly assigned to one of three groups. The main goal is to see how many people are cured of the infection, and the study also tracks side effects and how well patients stick to the treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vonoprazan and amoxicillin (dual therapy) or vonoprazan, amoxicillin, levofloxacin or clarithromycin, and bismuth (quadruple therapy)
What this could lead to: If successful, this could offer a simpler, shorter treatment for H. pylori infection with fewer side effects than current standard therapy.
What could go wrong: This is a mid-stage trial with 372 participants, so results may not apply to everyone. The dual therapy might not be as effective as the quadruple therapy, and side effects are still possible.

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Conditions

The condition(s) this trial relates to.

Helicobacter pylori infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HELICOBACTER PYLORI INFECTIONS

Contacts and locations

Locations

Qilu Hospital of Shandong University
RECRUITING

Jinan, Shandong, 250012, China
Qilu Hospital of Shandong University
NOT_YET_RECRUITING

Jinan, China

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