Could a cheap vitamin shield the aging brain during heart surgery?

NCT ID NCT06326996

Recruiting now Disease control Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study tests whether giving thiamine (vitamin B1) during coronary artery bypass surgery can reduce the memory and thinking problems that sometimes follow the procedure. Older adults with coronary heart disease who are scheduled for bypass surgery and have low thiamine levels may receive either a thiamine infusion or a placebo. Researchers will compare cognitive function, blood markers, and quality of life between the two groups to see if this simple intervention makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Thiamine (Vitamin B1) infusion
What this could lead to: If effective, a low-cost thiamine infusion could help preserve memory and thinking skills in older adults after heart bypass surgery.
What could go wrong: This is a small early-phase trial, so results may not apply broadly. Thiamine is generally safe, but its benefit for cognition is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Coronary Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY BYPASS GRAFTING CORONARY HEART DISEASE

Contacts and locations

Locations

UCLA
RECRUITING

Los Angeles, California, 90095, United States

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