Could magnetic pulses boost memory in Alzheimer's? new pilot study aims to find out

NCT ID NCT06597942

Recruiting now Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can safely improve memory in people with mild-to-moderate Alzheimer's disease. The treatment targets the precuneus, a brain region important for memory. Fifty-four participants will receive either active or sham (placebo) stimulation over several sessions, along with memory tests, brain scans, and bloodwork to look for positive changes. The study's main goals are to see if the treatment is feasible and tolerable, and to gather early signs of whether it might help memory.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus
What this could lead to: If it works, this could point toward a non-invasive brain stimulation treatment to help maintain or improve memory in people with Alzheimer's disease.
What could go wrong: This is a small, early-phase pilot study (Phase 1/2) with only 54 participants. Previous rTMS research in Alzheimer's has shown mixed results, and the main goal here is to test feasibility and safety, not to prove effectiveness. Common side effects include headache and scalp discomfort; rare but serious risks include seizure.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE ALZHEIMER&AMP;#39;S DEMENTIA ALZHEIMER&AMP;#39;S DISEASE (AD) ALZHEIMER&AMP;AMP;#39;S DISEASE DEMENTIA ALZHEIMER TYPE MILD ALZHEIMER&AMP;AMP;#39;S DISEASE MODERATE ALZHEIMER&AMP;AMP;#39;S DISEASE

Contacts and locations

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Study contacts

Contact

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Contact

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Locations

UCLA TMS Clinical and Research Service
RECRUITING

Los Angeles, California, 90095, United States

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