THC study: does age change how cannabis affects you?

NCT ID NCT05865470

Recruiting now Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how age and sex influence the effects of THC, the main psychoactive ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who use cannabis regularly. They will measure pain relief, intoxication, impairment, and how the body processes THC. The goal is to understand why people react differently to cannabis based on age and sex.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Delta-9-THC (the active ingredient in cannabis)
What this could lead to: If successful, this study could help doctors understand how THC affects people differently based on age and sex, potentially leading to safer cannabis use guidelines.
What could go wrong: This is an early-phase study with only 103 participants, so results may not apply to everyone. It focuses on short-term effects, not long-term safety or benefits.

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Conditions

The condition(s) this trial relates to.

cannabis dependence Coitus Pain poisoning substance abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABUSE, DRUG INTOXICATION; CANNABINOIDS PAIN

Contacts and locations

Locations

UCLA Center for Cannabis and Cannabinoids
RECRUITING

Los Angeles, California, 90095, United States

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