Columbia University

This study looks at whether a home blood pressure monitoring program helps people with high blood pressure get it under control. About 24,000 adults from primary care clinics will use home monitors and receive support. The goal is to see if this approach lowers blood pressure ove…

This early-phase study tests a new treatment called NKX019 for people with lupus, an autoimmune disease. NKX019 uses specially engineered immune cells to target and calm overactive B cells. The main goal is to check safety in 6 adults, while also seeing if it reduces lupus sympto…

This study tests whether a low dose of rapamycin, a drug that affects aging pathways, can slow down ovarian aging in women aged 35 to 45 who are in early menopause transition. Researchers will measure hormone levels and egg supply over time. The goal is to see if the drug can ext…

This study tests a two-step treatment for adrenocortical carcinoma that has spread inside the abdomen. First, surgeons remove all visible tumors. Then, heated chemotherapy (cisplatin) is pumped directly into the belly to kill remaining cancer cells. The goal is to see if this app…

This study tests whether adding special sugars found in breast milk (called human milk oligosaccharides) to the diet of HIV-exposed but uninfected infants can reduce infections and improve growth. About 140 babies will receive either the supplement or a placebo from 4 to 24 weeks…

This study tests whether taking nicotinamide and pyruvate (N&P) supplements can help maintain eye health in people with open-angle glaucoma. About 250 adults aged 35-85 will take N&P or a placebo for 20 months, while continuing their standard glaucoma medications. The goal is to …

This study tests whether doing extra MRI scans each week during radiation treatment can help doctors adjust the radiation plan to better target high-grade gliomas, a type of aggressive brain tumor. About 20 adults with newly diagnosed tumors will receive standard radiation plus w…

This study looks at the best way to provide HIV prevention medicine (PrEP) and hepatitis C treatment to people who inject drugs. About 446 participants will either get all their care at one location or be referred to a specialist elsewhere. The goal is to see which approach leads…

This study tests two natural substances, deoxythymidine and deoxycytidine, in 23 people with TK2 deficiency, a rare genetic condition that causes muscle weakness and breathing problems. The goal is to help cells make more mitochondrial DNA and reduce symptoms. The study focuses o…

This study tests whether a year of romosozumab followed by a year of denosumab can safely increase bone density in 30 premenopausal women aged 18-48 with idiopathic osteoporosis. Participants receive monthly injections of romosozumab for 12 months, then denosumab every 6 months f…

This study tests whether a special team that treats both severe infections and substance use disorders together can help hospitalized patients who inject drugs. About 480 adults will either get this integrated care or usual treatment. The goal is to see if the team approach lower…

This study tests a daily pill called axitinib in adults with a rare type of adrenal tumor (pheochromocytoma or paraganglioma) that has spread or cannot be removed by surgery. The main goal is to see how many patients' tumors shrink or disappear. Researchers also track how long th…

This study tests a program where doulas provide cognitive behavioral training and heart health coaching to new mothers after childbirth. The goal is to reduce postpartum depression and improve cardiovascular health. The program starts in the hospital and continues for six months …

This study tests a web-based program called CAMP Air designed to help urban teens, especially Black and Hispanic youth, better control their asthma. The program teaches teens how to prevent asthma symptoms and manage their condition. Researchers will measure if it reduces urgent …

This study aims to create and test a tool that uses chest CT scans to help doctors more accurately diagnose different types of pulmonary fibrosis, a condition where lung tissue becomes scarred. Researchers will analyze CT scans from 400 adults to identify patterns linked to speci…

This study tests a new ultrasound imaging method called electromechanical wave imaging (EWI) to see if it can better locate and understand heart rhythm problems before a standard procedure. About 322 adults scheduled for an electrophysiology study will get an EWI scan first. Half…

This study tests whether sending text messages and automated phone call reminders to parents can help more adolescent girls in Kampala, Uganda, get the HPV vaccine on time. About 396 parents of girls aged 10-14 will take part. The goal is to see if simple phone reminders improve …

This study tests whether metformin, a common diabetes medication, can prevent Alzheimer's dementia in people with mild cognitive impairment. About 326 overweight adults aged 55-90 without diabetes will take either metformin or a placebo for 18 months. Researchers will track memor…

This study looks at whether taking a short course of oral methylprednisolone (a steroid) after knee replacement surgery can help reduce pain, the need for strong painkillers, and nausea. About 116 adults with knee osteoarthritis who are having a first-time knee replacement will t…

This study tests whether transferring a person's own fat to the wrist can ease carpal tunnel syndrome better than standard steroid injections. The idea is that fat may help nerves heal and glide more smoothly. The trial involves 100 adults with mild to moderate symptoms, but it i…

This early-phase study tests whether glycerol phenylbutyrate (PBA), a drug already approved for other conditions, can improve vision in people with a rare inherited form of color blindness (achromatopsia) caused by ATF6 gene mutations. Two adults with the condition will take PBA …

This study tests whether rituximab or tocilizumab can help people with advanced solid tumors stop using steroids for immune-related side effects caused by immunotherapy. About 8 participants will receive one of these drugs to see if they can discontinue steroids within 4 weeks. T…

This study tests a behavioral therapy designed to reduce violent behavior in young adults (ages 16-30) who have early psychosis, including schizophrenia. The therapy is offered through early psychosis clinics. The main goal is to see if the therapy is acceptable and practical for…

This study tests a program that connects caregivers of adolescent and young adult cancer survivors with community resources to address unmet social and financial needs. About 60 caregiver-patient pairs will participate. The goal is to see if this navigation support is helpful and…

This study looks at two different ways to set a breathing machine (ventilator) for people with sepsis who need help breathing. Researchers will take special CT pictures of the lungs to see how air moves and stretches the lungs. They want to find out if a personalized ventilator s…

This study looks at how certain genes influence brain inflammation in people with Alzheimer's disease. Researchers use a special PET scan to measure immune cell activity in the brain. The goal is to find new genes that control this inflammation, which could lead to better treatme…

This study was designed to see if a smartphone app called iBlink can measure how aerobic exercise affects learning in people with spinocerebellar ataxia, a group of brain disorders that cause disability. The app tracks a simple eye-blink test that relies on the cerebellum, the br…

This study follows 1,520 mostly Black and Latinx adults in New York City who had COVID-19 to understand long-term health problems. Participants complete surveys about symptoms and allow researchers to review their medical records. A smaller group also provides blood and nasal swa…

This study looks at a rare genetic eye disease called CNGB1 retinitis pigmentosa, which causes gradual vision loss and blindness. Researchers will follow 20 people over 3 years using eye exams and imaging to track how the disease progresses. The goal is to find the best ways to m…

This study looks at whether restoring blood flow to the brain can reverse memory and thinking problems in people with severely narrowed neck arteries. About 385 participants from a larger trial will get brain scans and memory tests over one year. The goal is to see if those with …

This study looks at heart failure patients with a severe leaky tricuspid valve who received a new valve through a tube in a blood vessel (transcatheter replacement). It focuses on those who had unstable blood pressure right after the procedure. Researchers want to understand how …

This study was designed to test if a technique called self-distancing—where children use 'you' or their own name instead of 'I' when talking to themselves—helps them approach a feared spider during therapy. It planned to enroll children aged 7 to 12 with spider phobia and measure…

This study is testing a safety planning intervention designed for children ages 6-12 who have had suicidal thoughts or behaviors in the past month. Researchers want to see if the plan is clear and helpful to children and their caregivers, and whether it can reduce suicidal behavi…

This study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early. Participants get two screenings a year apart to track t…

This study looks at whether teens and young adults with Polycystic Ovary Syndrome (PCOS) have more fat in their liver than those without PCOS. Researchers will use MRI scans and other tests to measure liver fat, insulin resistance, and cholesterol problems. The goal is to better …

This study looks at how diet and body composition (muscle vs. fat) affect treatment outcomes in Indian children with acute lymphoblastic leukemia (ALL). Researchers will track 115 children to see how often sarcopenic obesity (loss of muscle, gain of fat) occurs and how it relates…

This study looks at 400 people who had a medication abortion either through telemedicine or in-person at Columbia University. Researchers want to see if there are differences in how often patients need extra follow-up care and to understand why they seek it. The goal is to learn …

This study looks at the health records of 400,000 birthing people to find better ways to predict and prevent maternal sepsis, a leading cause of death during and after childbirth. It focuses on understanding how social factors like poverty and race affect risk, especially for Bla…

This study looks at how the health of blood vessels and a person's genes might be linked to early signs of COPD and emphysema. Researchers followed over 4,300 adults from a larger heart study, measuring lung function and using CT scans to check for lung damage. The goal is to bet…

This study looks at how working at night changes what and how much people eat compared to day workers. Researchers will measure hunger, fullness, and appetite hormones in 100 healthy adults in New York City. The goal is to find out why night workers are more likely to become obes…

This study looks at how social factors like poverty and race affect care for new mothers with sepsis, a leading cause of maternal death in the U.S. Researchers will interview 200 patients and community experts to understand their experiences and improve care. The goal is to creat…

This study tests whether a gentle red light treatment, called photobiomodulation, can help embryos grow better during IVF. The light is meant to boost energy in the cells, especially for older women whose cells may not work as well. Researchers will compare embryos that get the l…

This study tests a simple decision aid called Lock and Protect in the emergency department. It helps parents of teens who came in for suicidal thoughts or self-harm to safely store medications and firearms at home. The goal is to see if the tool is acceptable and feasible, and if…

This study aims to find the genetic causes of mitochondrial disorders by analyzing tissue samples from up to 6900 people who either have or are related to someone with a suspected mitochondrial disease. Researchers will look for new mutations in DNA that may explain these conditi…

This study aims to find the most effective way to invite people with uncontrolled high blood pressure to a medication adherence counseling session. Researchers will test different recruitment letters and phone call strategies with 584 adults from under-resourced communities. The …

This study aims to understand why some people with Alpha-1 antitrypsin deficiency, a genetic lung and liver disease, get worse quickly while others stay stable. Researchers will follow 286 patients for three years, using CT scans and blood tests to look for early signs that predi…