Columbia University

This study looks at whether providing medically tailored groceries can help people with type 2 diabetes and high blood pressure keep up healthy eating habits and control their blood sugar and blood pressure. About 80 adults who already took part in a meal delivery study will rece…

This study looks at whether children and teens being treated for acute lymphoblastic leukemia can follow a low-glycemic (low-sugar) diet for six months. The goal is to see if this diet is practical and helps manage weight during cancer treatment. About 88 participants will track …

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This phase 2 trial tests whether giving heated chemotherapy directly into the abdomen during surgery can help people with a rare and aggressive adrenal cancer that has spread within the belly. About 30 participants will have surgery to remove visible tumors, followed by a wash of…

This study tests whether adding weekly MRI scans during radiation treatment can help doctors better target high-grade gliomas, a type of aggressive brain tumor. About 20 adults with newly diagnosed tumors will receive standard radiation plus extra imaging to see if it improves tr…

This study tests whether shining a special red light on embryos during IVF can help them grow better. As women age, the energy centers in their cells (mitochondria) weaken, making it harder for embryos to develop. The light therapy aims to boost that energy. Researchers will comp…

This study looks at whether a home blood pressure monitoring program helps people with high blood pressure get better control. About 24,000 adults from primary care clinics are taking part. The program includes support and education to help patients measure and manage their blood…

This phase II trial tests the drug axitinib in 6 adults with metastatic or inoperable pheochromocytoma or paraganglioma, rare tumors of the adrenal glands or nerve tissue. Axitinib works by blocking blood vessel growth that feeds tumors. The main goal is to see how many patients'…

This study tests whether a monthly injection of romosozumab for one year, followed by another drug (denosumab) for another year, can safely increase bone density in 30 premenopausal women aged 18-48 who have osteoporosis without a known cause. The goal is to improve bone mass and…

This study tests two natural substances, deoxythymidine and deoxycytidine, in people with TK2 deficiency, a rare genetic condition that causes muscle weakness and breathing problems. The goal is to see if these nucleotide precursors can help cells make more mitochondrial DNA and …

This study tests a program called Living Healthy for Moms, where doulas provide cognitive behavioral training and heart health coaching to new mothers. The goal is to reduce postpartum depression and lower the risk of heart problems. The trial includes 21 mothers who recently gav…

This Phase 2 trial tests whether low-dose rapamycin can slow ovarian aging in 50 women aged 35-45 who are in early perimenopause. Participants take 5mg of rapamycin or a placebo weekly for 12 weeks. Researchers will measure hormone levels and ovarian reserve to see if the drug de…

This study tests a web-based program called CAMP Air to help urban teens, mostly Black and Hispanic, better control their asthma. The program teaches steps to prevent symptoms and manage the condition. Researchers will check if it reduces asthma attacks and urgent care visits.

This study tests whether taking nicotinamide and pyruvate supplements can help protect the eyes of people with open-angle glaucoma. About 250 adults aged 35 to 85 will take either the supplements or a placebo for 20 months, while continuing their standard glaucoma medications. Th…

This study tests whether a special care team that combines treatment for severe injection-related infections and substance use disorders can improve outcomes. 480 hospitalized adults who inject drugs will either receive this integrated care or usual treatment. The main goal is to…

This small pilot study tests a behavioral therapy called PICASSO, designed to help young adults (ages 16-30) with early psychosis who have shown violent behavior. The therapy uses cognitive behavioral techniques to address anger and violence. The study will check if the therapy i…

This study tests a new, non-invasive ultrasound method called electromechanical wave imaging (EWI) to see if it can more accurately locate and diagnose heart rhythm problems compared to standard tests. About 322 adults already scheduled for a heart procedure will get an EWI scan …

This study is testing a new tool that uses chest CT scans to help doctors more accurately diagnose different types of pulmonary fibrosis, a lung scarring disease. Researchers will first create the tool by analyzing scans from 300 patients, then test it on 100 additional patients.…

This study tests whether providing HIV prevention (PrEP) and hepatitis C treatment together at one location works better than sending patients to separate clinics. About 446 people who inject drugs will be randomly assigned to either on-site integrated care or off-site referrals …

This study tests whether metformin, a drug used for diabetes, can prevent Alzheimer's dementia in people with mild cognitive impairment (MCI). Over 18 months, 326 overweight adults aged 55-90 with MCI will receive either metformin or a placebo. Researchers will track memory, brai…

This study tests whether sending text messages or automated phone reminders to parents helps girls aged 10-14 get the HPV vaccine on time. About 400 parents in Kampala, Uganda, are taking part. The goal is to see if simple reminders can improve vaccination rates and protect again…

This study tests whether a short course of oral methylprednisolone (a steroid) after knee replacement surgery can lower pain, reduce the need for strong painkillers, and lessen nausea. About 116 adults with knee osteoarthritis are taking part. The goal is to see if this simple me…

This study tests a program that helps caregivers of teens and young adults (ages 15-26) with cancer find resources for financial and social needs. About 60 caregiver-patient pairs will take part. The goal is to see if this support reduces stress and improves well-being.

This study tests whether rituximab or tocilizumab can help people with advanced cancer stop taking steroids for side effects caused by immunotherapy. About 8 participants will receive one of these drugs to see if they can safely reduce or stop steroid treatment within 4 weeks. Th…

This study tests a web-based tool called Lock and Protect that helps caregivers of teens at risk for suicide find safe ways to store medications, firearms, and other dangerous items at home. The tool guides parents through options and creates a safety plan. The trial will enroll …

This study tests whether injecting a patient's own fat (lipografting) into the wrist can improve symptoms of mild to moderate carpal tunnel syndrome better than standard steroid injections. The fat is thought to reduce scarring and help nerves glide more freely. The trial plans t…

This early-phase trial tests whether an FDA-approved drug called glycerol phenylbutyrate (PBA) can improve vision in people with a rare form of color blindness caused by mutations in the ATF6 gene. Only 2 participants are enrolled, and they will take PBA three times daily while t…

This study is testing a safety planning intervention designed for children ages 6-12 who have had suicidal thoughts or behaviors in the past month. Researchers want to see if the plan is clear and helpful to children and their caregivers, and whether it can reduce suicidal behavi…

This study follows 1,520 mostly Black and Latino individuals and their households who had COVID-19 in New York City. Researchers will use surveys and medical records to track long-term health problems, and for 500 hospitalized patients, they will collect nasal swabs and blood sam…

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This study looks at how certain genes influence the activity of immune cells in the brain, called microglia, in people with Alzheimer's disease. Researchers will use a special PET scan to measure these cells in about 107 older adults, some with mild memory problems or Alzheimer's…

This study was designed to see if a smartphone app called iBlink can measure how well the brain learns new movements in people with spinocerebellar ataxia, a rare and serious movement disorder. Researchers planned to compare aerobic exercise with balance training to see which bet…

This study was designed to test whether a technique called self-distancing—where children refer to themselves in the third person (e.g., 'Emily can touch the spider')—helps them approach feared objects more than using first-person self-talk ('I can touch the spider'). The trial p…

This study explores how problems with blood vessel function and genetics may contribute to early-stage COPD and emphysema. Researchers followed over 4,300 adults from a larger heart study, measuring lung function and CT scans. The goal is to understand risk factors, not to test a…

This study looks at a rare, inherited eye disease called CNGB1 retinitis pigmentosa that causes gradual vision loss and blindness. Researchers want to learn how the disease progresses by using eye exams and imaging tests over three years. The goal is to find the best ways to meas…

This study looks at how working night shifts changes eating behaviors and appetite compared to day shifts. Researchers will measure food intake, hunger hormones, and fullness in 100 healthy adults who work either day or night shifts. The goal is to understand why night workers ar…

This study looks at how the heart changes after a procedure to replace a leaky tricuspid valve in people with severe heart failure who cannot have open-heart surgery. It focuses on patients who develop unstable blood pressure right after the procedure. Researchers will track surv…

This study looks at whether getting a medication abortion through telemedicine (virtual visits) leads to different results or more follow-up visits compared to in-person care. Researchers will review records from 400 patients who had abortions at Columbia University. The goal is …

This study looks at how social factors like poverty and race affect care for mothers with sepsis, a leading cause of death after childbirth in the U.S. Researchers will interview 200 Spanish- or English-speaking women who recently gave birth and had infection warning signs, plus …

This observational study looks at 400,000 birthing people to better predict maternal sepsis, a leading cause of death in the U.S. The goal is to improve risk prediction by considering social factors like poverty and race, and to create a care model that reduces death and disabili…

This study follows 286 adults with Alpha-1 Antitrypsin Deficiency, a genetic condition that can damage the lungs and liver. Researchers use CT scans and blood tests over three years to see how lung density changes. The goal is to find biological markers that could help design bet…

This pilot study looks at how diet and body fat versus muscle (sarcopenic obesity) affect treatment and recovery in Indian children with acute lymphoblastic leukemia. Researchers will track 115 children's food intake and body composition using DEXA scans. The goal is to understan…

This study aims to discover new genetic mutations that cause mitochondrial disorders by analyzing tissue samples from up to 6,900 participants. It includes people with suspected or known mitochondrial diseases, such as MELAS or Leigh's Disease, who lack a genetic diagnosis. The r…

This study looks at how to best reach adults with uncontrolled high blood pressure who struggle to take their medications as prescribed. Researchers will test different recruitment letters and phone call strategies to see which approach gets more people to attend a counseling ses…

This study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…

This study looks at whether teenagers and young adults with Polycystic Ovary Syndrome (PCOS) have more fat in their liver than those without PCOS. Researchers will use advanced imaging and tests to measure liver fat, insulin resistance, and cholesterol problems in 80 participants…

This study looks at two ways of setting a breathing machine (ventilator) for people with sepsis who need help breathing. One method is personalized based on each patient's lung measurements, while the other is a standard approach. Researchers will use CT scans to see how air move…