Columbia University

This study is testing whether a low dose of the drug rapamycin can slow down ovarian aging in perimenopausal women. Researchers want to see if it can extend the reproductive window and delay menopause-related health changes. The trial involves 50 women aged 35-45 who will receive…

This study aims to find the best way to provide HIV prevention medication and hepatitis C treatment to people who inject drugs. It compares two approaches: getting care directly at a drug treatment or needle exchange site versus being referred to a specialist clinic. Researchers …

This study is testing a two-drug treatment to improve bone density and strength in premenopausal women who have osteoporosis without a known cause. Thirty participants will receive a monthly injection of romosozumab for one year, followed by another drug, denosumab, every six mon…

This study is testing if a gentle red light treatment can help embryos grow better during IVF. As women get older, the energy-producing parts of their egg cells can become less efficient, which may make it harder for embryos to develop. Researchers want to see if shining a specia…

This study aims to find the best way to set a breathing machine (ventilator) for patients with sepsis to protect their lungs from damage. Researchers will use CT scans to compare a personalized ventilator setting against a common standard setting in 7 participants. The goal is to…

This study tests a support program designed to help caregivers of adolescent and young adult cancer patients manage financial stress and access community resources. The program connects caregivers with financial education and local support services. Researchers aim to see if this…

This study is testing whether two over-the-counter supplements, nicotinamide (vitamin B3) and pyruvate, can help slow vision loss in people with glaucoma. About 188 participants will take either the supplement combination or a placebo for 20 months while continuing their standard…

This study is testing whether injecting a person's own fat into their wrist can treat mild to moderate carpal tunnel syndrome better than the standard steroid injection. Researchers think the fat might help reduce scarring and promote nerve healing. The trial will enroll 100 adul…

This large study is testing whether a supported home blood pressure monitoring program can help people with high blood pressure get better control of their condition. The program is being rolled out across many primary care practices serving diverse patient populations. Researche…

This study is testing whether the drug axitinib can shrink or slow the growth of rare adrenal gland tumors called pheochromocytoma and paraganglioma that have spread or returned after treatment. It involves 6 adult participants with confirmed, measurable disease. The main goal is…

This study aims to find the best methods for inviting patients to a counseling session that helps them take their blood pressure medicine more regularly. Researchers will test different invitation letters and call attempts to see which combination gets the most people to attend a…

This study is testing whether a special nutritional supplement can help babies who were exposed to HIV in the womb but are not infected. These babies often face more infections and slower growth. Researchers in South Africa are giving some babies a supplement containing prebiotic…

This study is testing a web-based program called CAMP Air, designed to help urban teenagers, primarily Black and Hispanic youth, better manage their uncontrolled asthma. The research involves 374 teens and aims to see if the online program improves asthma control, reduces urgent …

This study is testing whether two oral supplements (deoxythymidine and deoxycytidine) can help people with a rare genetic disorder called TK2 deficiency. TK2 deficiency causes severe muscle weakness by preventing the body from making enough cellular energy. Researchers hope these…

This study is trying to find out if clearing a severely blocked neck artery can reverse memory and thinking problems in people who have no other stroke symptoms. It is enrolling 385 people from a larger stroke prevention trial who have both the artery blockage and signs of reduce…

This study is testing whether a special hospital care team that treats severe infections and substance use disorders at the same time leads to better health. The team provides coordinated medical care and support for addiction during the hospital stay and for four months after di…

This early-stage study is testing whether an existing drug called glycerol phenylbutyrate (PBA) can improve vision in people with a rare, inherited form of color blindness caused by a specific gene mutation (ATF6). Two adult patients will take the drug three times a day and have …

This study is testing a new computer tool that analyzes chest CT scans to help doctors more accurately diagnose the specific type of lung scarring a patient has. Researchers will create the tool using scans from about 300 patients and then test it on scans from 100 more. They wil…

This 5-year study offers free vision screenings to New York City residents over 40 living in affordable housing. The goal is to find eye diseases like glaucoma and cataracts early in people who might not regularly see an eye doctor. Researchers will check vision and help connect …

This study is testing whether sending text message or automated phone call reminders to parents helps adolescent girls in Uganda start and finish their HPV vaccine series. HPV vaccination prevents cervical cancer, which is the leading female cancer in Uganda, but many girls do no…

This study is testing a tablet-based tool called 'Lock and Protect' given to parents in a children's hospital emergency room. The goal is to see if the tool is practical and acceptable for helping parents safely store guns and medications at home to reduce their teen's suicide ri…

This study is testing a special support program for new mothers, delivered by trained doulas, to prevent postpartum depression and heart health problems. The program starts in the hospital and provides support for six months, focusing on Black, Latina, and Medicaid-eligible mothe…

This small pilot study is testing a new behavioral therapy program designed to help reduce violent behavior in young adults (ages 16-30) who are in the early stages of a psychotic disorder. The main goal is to see if the therapy is practical and acceptable for both patients and t…

This study is testing two drugs, rituximab or tocilizumab, to help people with advanced cancer who develop severe, long-lasting side effects from their immunotherapy treatment. These side effects often require patients to take high doses of steroids, which can cause serious healt…

This study aims to understand if adolescents and young adults with Polycystic Ovary Syndrome (PCOS) are more likely to have high liver fat and related metabolic problems like insulin resistance. Researchers will compare 40 young people with PCOS to 40 without it, using scans and …

This study is testing whether a 40-hour mental health training program for police officers improves their skills during crisis calls. Researchers are comparing 240 officers who receive the training with those who don't, measuring their de-escalation techniques and decision-making…

This study aims to design a community-based care model to prevent maternal sepsis, a leading cause of death for new mothers. Researchers will interview 200 recent mothers and community health experts in New York City to understand their experiences and gather ideas. The goal is t…

This study aims to understand why night shift workers have a higher risk of obesity by comparing their eating behaviors, hunger levels, and fullness signals to those of day workers. Researchers will measure how much food people eat, their body's hunger hormones, and their feeling…

This study looks back at medical records to compare how well telemedicine and in-person medication abortions work. Researchers are checking if there are differences in treatment success, complications, and whether patients need extra follow-up visits. The goal is to understand pa…

This study looks at a serious complication called acute hemodynamic instability (AHI), which is a dangerous drop in blood pressure, after a minimally invasive heart valve replacement. Researchers will review medical records of 140 high-risk heart failure patients who were too sic…

This study aims to discover the unknown genetic causes of mitochondrial diseases, which affect the body's energy production. Researchers will analyze leftover tissue samples from thousands of patients who have a suspected mitochondrial disorder but no confirmed genetic diagnosis.…

This study aims to understand why some mothers develop life-threatening infections after childbirth, especially those from underserved communities. Researchers will analyze the health records of 400,000 mothers to find patterns and create better prediction tools. The goal is to u…

This study aims to understand how a child's nutrition at the start of leukemia treatment affects their body composition—specifically the loss of muscle and gain of fat. Researchers will observe 115 Indian children with acute lymphoblastic leukemia (ALL) to see if these body chang…

This study aims to find early signs that predict which people with Alpha-1 antitrypsin deficiency, a genetic disease that can damage the lungs and liver, will get worse quickly. Researchers are following 286 adults with the disease for three years, using CT scans and blood tests …