Can a Low-Dose drug delay menopause? new trial aims to find out
NCT ID NCT05836025
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether low-dose rapamycin can slow ovarian aging in 50 women aged 35-45 who are in early perimenopause. Participants take 5mg of rapamycin or a placebo weekly for 12 weeks. Researchers will measure hormone levels and ovarian reserve to see if the drug delays age-related decline.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rapamycin (low dose, 5mg/week for 12 weeks)
What this could lead to
If it works, this could point toward a way to slow ovarian aging and extend fertility in perimenopausal women.
What could go wrong
This is a small, early-phase pilot study with only 50 participants. Results may not apply to all women, and the effect on fertility is not directly tested.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Columbia University Irving Medical Center / NewYork-Presbyterian Hospital
New York, New York, 10032, United States