Columbia University

This study tests whether a synbiotic supplement (a mix of a prebiotic called 2'-FL HMO and a probiotic called B. infantis) can reduce infections and improve growth in infants who were exposed to HIV but are not infected themselves. About 140 infants will receive either the supple…

This study tested a combination of two drugs, brentuximab vedotin and bendamustine, in 65 patients with Hodgkin lymphoma or anaplastic large cell lymphoma that had come back or didn't respond to earlier treatments. The goal was to find the safest dose and see how well the drugs w…

This early-phase study tested a method called convection-enhanced delivery to pump the chemotherapy drug topotecan directly into brain tumors in 16 patients with recurrent malignant brain tumors. The goal was to see if this approach is safe and to find the best dose, while also m…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study tested a smartphone app called T2.coach that tracks diet, blood sugar, activity, and sleep, then uses machine learning to give personalized behavioral goals. About 280 adults with type 2 diabetes and high blood sugar used the app for 6 months alongside standard diabete…

This early-phase study tested whether pumping the chemotherapy drug topotecan directly into the brain is safe for people with recurrent high-grade gliomas (aggressive brain tumors). Only 5 patients took part, and the main goal was to find a safe dose. The drug was delivered conti…

This early-phase study tested two immunotherapy drugs (spartalizumab and canakinumab) given before surgery to 17 people with localized clear cell kidney cancer. The main goal was to see if this approach was safe and did not delay surgery. The study also looked at how the drugs af…

This study tested a web-based app called Mobile Diabetes Detective (MoDD) in 248 adults with type 2 diabetes. The app helps users identify problems with blood sugar control and suggests better behaviors. Researchers measured changes in blood sugar (HbA1c), problem-solving skills,…

This study looked at two different types of follow-up care for people with heart failure after they leave the hospital. One group got a phone call from a care coordinator, while the other could request a home visit from a community paramedic who could connect them to a doctor by …

This study tested two approaches to help people living in public housing smoke less and reduce secondhand smoke. One approach offered one-on-one support to smokers to help them cut back or quit. The other aimed to get all residents in a building to support smoke-free rules. The s…

This study tested a stepped care system to help Congolese refugees and local community members in Zambia reduce unhealthy alcohol and drug use. The program started with a quick screening and brief advice, then offered more support if needed. 400 adults took part, and the main goa…

This study tested whether applying vancomycin powder directly to the surgical wound during brain surgery can reduce infections. Over 1,100 adults having neurosurgery were randomly assigned to receive either the topical vancomycin or standard care. The main goal was to see if the …

This pilot study tested whether a hybrid cardiac rehabilitation program, combining a few clinic visits with mostly home-based telehealth sessions, is feasible for heart attack survivors. Ten participants were enrolled to see if they would join and stick with the program. The stud…

This study tested whether a set of anesthesia techniques could lower the risk of serious lung complications after open abdominal surgery. About 794 adults at high risk for lung problems took part across 14 US hospitals. The approach included personalized ventilation and fluid man…

This study tested whether taking vitamin D every day could reduce lung complications in children and teens with sickle cell disease. Lung problems like infections, asthma attacks, and acute chest syndrome are major causes of illness and death in this condition. Researchers gave d…

This study tested whether the antiviral drug valacyclovir (Valtrex) can slow memory loss in people with mild Alzheimer's disease who also carry the herpes simplex virus. About 120 participants received either the drug or a placebo for 18 months. The goal was to see if treating th…

This study tested a combination HIV prevention approach for 120 men in Kisumu, Kenya, who had recently exchanged sex for money or goods. Participants took daily PrEP pills and received real-time feedback from a urine test, HIV self-test kits, and text reminders. The goal was to s…

This study tested a program to help gay and bisexual men in Romania begin and continue taking PrEP, a daily pill that prevents HIV. The program combined in-person counseling, an educational app, and support from doctors. Researchers wanted to see if this approach was practical an…

This study tested a behavioral program called PREPP, which provides coaching sessions to pregnant women at risk for postpartum depression. The program focuses on improving infant sleep and reducing fussiness, aiming to lower depression risk. 216 women participated, receiving eith…

This study tested a mobile program called Comunică to help Romanian gay and bisexual men reduce HIV risk and heavy drinking. 300 participants used their phones or laptops to complete surveys and eight one-hour sessions with a counselor or by reading health information. The progra…

This study tested a new program called CATCHES for people who had a stroke and are afraid of falling. The program combines physical therapy at home with coaching to reduce fear. 30 adults who had a mild to moderate stroke took part. The goal was to see if the program is practical…

This study looked at 151 women having C-sections to see if using skin glue (Dermabond Prineo) to close the incision works better than standard stitches. The main goal was to find out which method made patients happier with how their scar looked and felt. Researchers also checked …

This study tested whether personalizing cognitive training based on a person's early auditory processing ability improves thinking and daily function in schizophrenia. 194 adults with schizophrenia or schizoaffective disorder were assigned to either a tailored program (Brain Basi…

This pilot study tested whether screening for depression and offering group therapy could help adolescents in Mozambique. Researchers compared a 10-session group therapy called IPT-AG to usual care at four youth-friendly health clinics. The study enrolled 95 teens and measured ch…

This study tested whether showing patients with atrial fibrillation (AF) simple visual charts of common post-ablation symptoms could help them decide more confidently about undergoing the procedure. 75 adults with symptomatic AF who were considering catheter ablation used these d…

This study tested whether a special adaptor that makes smaller eye drops works as well as standard drops for numbing the eye. 56 adults received numbing drops in each eye—one with the standard bottle and the other with the Nanodropper adaptor. Researchers measured how numb each e…

This small study tested whether nitrous oxide (laughing gas) can quickly relieve severe pain in children with sickle cell disease during a pain crisis. Five patients aged 8 to 18 who still had high pain after standard treatment received nitrous oxide in the emergency room. Resear…

This study tested whether giving a very high dose of lovastatin (a common cholesterol drug) for 3 days after a stroke is safe. 162 stroke patients received either the high-dose drug or a placebo within 24 hours of symptoms. The main goal was to check for liver or muscle damage, w…

This study tested whether a website called Heartsight could help close family members of cardiac arrest patients feel less uncertain, anxious, and burdened. Fifty-three family members were given access to the website or usual care. The goal was to see if the website was easy to u…

This study tested a short, scripted conversation between doctors, children with asthma, and their caregivers to improve asthma control. The program, called BREATHE-Peds, was designed for urban youth aged 10-14 who receive care at community health centers. The goal was to see if i…

This study tested whether balance training or aerobic cycling can improve movement and brain function in 64 people with cerebellar ataxia, a condition that affects coordination. Participants did one type of exercise five times a week for 30 minutes. Researchers used brain scans t…

This study tested whether a mobile app called Messy Memories could help people who had been in the intensive care unit (ICU) deal with distressing memories. The app guides users to record and process a difficult memory on their own. Researchers wanted to see if people would actua…

This completed study tested a 16-session online therapy program for transgender and gender-diverse adults in Romania who had symptoms of depression or anxiety. The therapy was designed to address stress related to discrimination and lack of affirming healthcare, and also included…

This study looked at whether the SNOO Smart Sleeper, which plays white noise and gently rocks, helps preterm infants sleep more peacefully and have better vital signs compared to a traditional bassinet. Twenty preterm infants in the NICU each spent two three-hour sessions sleepin…

This study looks at people with severe but symptom-free narrowing of the carotid artery in the neck. It tests whether opening the artery with surgery or stenting can improve memory and thinking problems caused by poor blood flow to the brain. About 385 participants from a larger …

This study tested whether helping people sleep longer (through sleep hygiene and extending sleep time) could lower their blood pressure during sleep. 66 adults who slept less than 7 hours per night took part. Researchers measured blood pressure during sleep and awake periods at t…

This study compared two programs for new mothers and their babies, starting in the hospital nursery and continuing until the baby is 4 months old. One program focused on emotional exchange, where mothers shared stories and discussed feelings with their baby. The other provided st…

This study tested a combined program (WINGS+PM+) for women experiencing intimate partner violence (IPV) and mental distress in Kenyan informal settlements. 260 women were randomly assigned to either the combined program or a shorter psychological support alone. The goal was to se…

This study tested a program called Room to Grow that gives low-income mothers counseling, baby supplies, and community referrals for three years. Researchers wanted to see if this support improves children's development, parenting skills, and mothers' mental health. The trial enr…

This study looked at whether a 40-hour Crisis Intervention Team (CIT) training program helps police officers improve their verbal de-escalation skills and decision-making when responding to mental health crises. About 242 officers were randomly assigned to receive the training or…

This study tested a program called Free Time for Wellness (FT4W) designed to help low-income mothers in New York City become more physically active. 89 mothers with young children took part. The program aimed to overcome barriers like lack of time and resources by offering suppor…

This study tested whether giving people subsidized rideshare vouchers (like Uber credits) could reduce drunk driving and alcohol consumption. Over 7,000 adults who drink at bars and own a car participated. Researchers compared those who received rideshare vouchers to those who re…

This study gathered feedback from 50 people who completed the Medicaid sterilization consent form. Participants filled out a short survey and some joined a one-on-one interview to share their thoughts and experiences. The goal is to learn how well patients understand the form and…

This study tested whether playing a web-based breakfast game could improve executive control (like multitasking and planning) in healthy adults aged 60-75. 38 participants played the game, with some using specific strategies. The goal was to see if the training improved game perf…

This study aimed to understand and address financial stress in teens and young adults (ages 15-39) recently treated for cancer. Researchers tested a financial education and navigation program to see if it was helpful and practical. The study involved 26 participants and focused o…

This study followed about 1,900 pregnant women and their babies for two years to see how HIV and the medication dolutegravir affect weight gain and overall metabolic health. Researchers compared women with HIV to those without, and also looked at differences between women who sta…

This study tested whether a set of strategies—including community teamwork, tech-based training, and peer support—could improve HIV testing and substance use care for people about to be released from jail. Researchers worked with 65 incarcerated individuals in one New York county…

This study tested whether sending e-mails to doctors could encourage them to use a state-run prescription monitoring program and reduce unsafe opioid prescribing. About 7,800 Minnesota physicians and physician assistants who were not using the program as required took part. The r…

This completed study tested a web-based decision aid called RealRisks in 70 high-risk women aged 35-74. The tool combines electronic health records and patient-reported data to calculate breast cancer risk and improve understanding of prevention options. Researchers measured whet…

This study looked at how type 1 diabetes affects bone health in children and teens. Researchers compared bone density and structure in 86 children with and without diabetes using special scans. The goal was to understand if diabetes makes bones more fragile, which could lead to b…

This study looked at over 650 U.S. public schools to see if safety tactics like metal detectors, security guards, and emergency drills actually prevent intentional shootings. Researchers also checked whether these measures lead to more student suspensions or expulsions. The goal …

This study looked at how weight-loss surgery affects brain chemicals that control appetite. Researchers measured spinal fluid from 51 people before and after gastric bypass or sleeve gastrectomy, and compared them to people who lost weight through dieting. The goal is to understa…

This completed Phase 1 study from Columbia University enrolled 18 overweight or obese adults with insulin resistance and non-alcoholic fatty liver disease (NAFLD). Researchers used a technique called a pancreatic clamp to carefully control insulin levels and measure how blood sug…

This study tested whether a drug called diazoxide, which lowers high insulin levels, can help researchers understand how fatty liver disease develops. Twenty-four adults with overweight or obesity and insulin resistance took either a low or high dose of diazoxide or a placebo for…

This study looked at how sleep and diet affect performance in 38 Columbia University baseball players. Researchers measured sleep quality, food intake, and athletic skills like batting and pitching speed. The goal was to understand these links and later test ways to improve them.

This study looked at whether training community health workers to screen for depression in Black churches helps more people get treatment. Over 500 adults from 30 churches took part. One group got a brief intervention and referral, while the other got usual referral. The goal was…

This completed study looked at why people with spinal muscular atrophy (SMA) often feel very tired and have trouble exercising. Researchers tested 34 ambulatory SMA patients who were already on standard treatments (risdiplam or nusinersen) for at least six months. Participants di…

This study looked at how well people think and remember after surgery to clear a blocked neck artery (carotid endarterectomy). About 800 patients took brain tests before and after surgery, and their results were compared to people having spine surgery. The goal was to find out ho…

This study looked at how giving people information about their genetic risk for Alzheimer's disease affects them emotionally and behaviorally. It involved 374 Latino adults aged 40-64 in New York City who did not have Alzheimer's. Some participants learned their risk based only o…

This study looked at whether genetic testing during pregnancy can help manage fetuses with ultrasound abnormalities. Over 1,000 participants were involved to see if finding genetic causes improves care, reduces unnecessary tests, and lowers costs. The goal is to better understand…

This study tested a school program called Old SCHOOL Hip-Hop that uses music and dance to teach 4th and 5th graders (ages 9-11) and their parents about Alzheimer's disease. Over 2,200 families from New York City public schools took part. The goal was to see if the program improve…

This study looked at how long-term lack of sleep affects heart health and weight in women. Researchers compared premenopausal and postmenopausal women to see if sleep loss raises blood pressure, blood sugar, and belly fat. The goal was to understand if sleep is more important for…

This study tested a clinical decision support tool called PREVENT to help nurses prioritize which patients need homecare most urgently after leaving the hospital. Researchers studied nearly 2,000 adults with conditions like diabetes, heart failure, and lung disease to see if the …

This study looked at whether mother-daughter pairs who change their household habits—like using chemical-free products and better cleaning—can lower their exposure to harmful chemicals and alter breast tissue composition. The goal was to see if these changes could reduce breast c…

This study tested a system where police officers can call a mental health provider during encounters with people who have serious mental illness. The goal was to see if this reduces arrests and helps people stay connected to care. Over 1,400 participants were randomly assigned to…

This study tested whether different practice conditions help stroke survivors learn to use their more affected arm. Twenty-eight participants with arm weakness after a stroke practiced a scooping task over two days. Researchers measured how well they performed the task immediatel…