Columbia University

This early-stage study is testing whether a non-invasive focused ultrasound device can safely and temporarily open the protective blood-brain barrier in children with progressive diffuse midline glioma, a severe brain tumor. The goal is to allow more of an oral chemotherapy drug …

This study is testing whether a personalized sleep coaching program can help lower blood pressure and improve heart health. Researchers will enroll 200 adults with sub-optimal sleep habits and slightly elevated blood pressure. One group will receive standard heart health educatio…

This study aims to find the best drug to prevent a common and serious viral infection (CMV) in people who have received a heart transplant. It will compare the safety and effectiveness of a newer drug, letermovir, against the current standard, valganciclovir, in 150 adult transpl…

This study is testing a brief, 9-minute conversation tool called BREATHE that helps doctors and Black adult patients with uncontrolled asthma make treatment decisions together. The goal is to see if this approach improves asthma control, medication use, and quality of life for 40…

This study is testing whether a light-based blood treatment called photopheresis can help control early-stage cutaneous T-cell lymphoma (CTCL), a type of skin cancer. Researchers want to see if using this treatment earlier in the disease course, rather than just for late stages, …

This study is testing a Spanish-language mobile app called WiseApp, paired with a smart pill box, to help Spanish-speaking people living with HIV remember to take their daily medication. Researchers will enroll 248 participants in New York City and the Dominican Republic to see i…

This study is testing whether keeping daily habits like sleep and meals more stable can improve blood sugar control and body composition in people with pre-diabetes. Researchers will enroll 34 adults with pre-diabetes and irregular routines, asking one group to stabilize their ha…

This study is testing if a special video game program can help children with obsessive-compulsive disorder (OCD). Kids aged 8-12 will play the game at home for 4 weeks to see if it improves their focus and thinking skills. Researchers hope this 'brain training' will make standard…

This study is testing whether a homecare program can help people recover better after a stroke, especially if they face social challenges like unstable housing, low income, or lack of support. The program sends a team including a nurse, social worker, and community health worker …

This study tests whether giving direct cash payments to pregnant women improves health outcomes for both mothers and babies. Researchers will enroll 1,250 pregnant women in Appalachian regions and randomly assign them to receive either high or low cash support. They'll track whet…

This study is testing whether a structured physical activity program can improve thinking skills and daily living abilities in children who have had surgery for congenital heart disease. Researchers will compare 300 children who had heart surgery with children who had other surge…

This study is testing whether providing free, healthy meals and heart-healthy cooking lessons can help people with type 2 diabetes and high blood pressure eat better and improve their health. Researchers will enroll 160 participants from underserved NYC neighborhoods to compare d…

This study is testing if adding an immunotherapy drug called cemiplimab to a standard three-drug chemotherapy regimen can shrink tumors in patients with locally advanced, inoperable bile duct cancer. The main goal is to see if this four-drug combination can shrink the tumors enou…

This study is testing whether regularly doing crossword puzzles can help slow down memory and thinking problems in older adults with mild cognitive impairment (MCI), a condition that often leads to dementia. Researchers will compare doing four puzzles a week to one puzzle a week,…

This study is testing whether a support tool called iHeart DepCare can help more heart disease patients with depression start or improve their mental health treatment. Researchers will work with 200 patients who have both heart disease and symptoms of depression. The tool provide…

This study is testing whether drinking a special nutrition shake before getting a heart pump (LVAD) can help patients recover better. Researchers want to see if the shakes improve gut health, reduce body-wide inflammation, and lower the risk of serious infections after surgery. T…

This study is testing a two-part treatment for a rare and aggressive adrenal gland cancer that has spread within the abdomen. Doctors first remove as much visible tumor as possible through surgery, then wash the abdominal cavity with heated chemotherapy. The goal is to see if thi…

This small pilot study is testing whether adjusting a patient's radiation plan daily, based on how their tumor and body change, is a practical approach. The goal is to see if this method can better focus radiation on the shrinking tumor while reducing exposure to nearby healthy o…

This study aims to find the safest blood-thinning treatment for people living with advanced heart failure who rely on a mechanical heart pump (called an LVAD). It will compare two approaches in 128 patients: continuing with aspirin plus a standard blood thinner versus using only …

This study is testing if giving teens with iron deficiency an IV iron dose before major spinal fusion surgery for scoliosis helps them recover better. Researchers want to see if this simple step reduces the need for blood transfusions during surgery and improves thinking skills a…

This study is testing whether taking low-dose aspirin for three weeks after giving birth can help women who had severe preeclampsia. Preeclampsia is a serious pregnancy condition that raises blood pressure and can damage organs, and its effects can last after delivery, increasing…

This study aims to help HIV clinics reduce stigma that can prevent people from getting and staying in care. Five clinics in the southern and eastern US will work with researchers to create and test staff training programs focused on respectful policies and attitudes. The goal is …

This study is testing a faster, one-visit approach to prevent cervical cancer in women living with HIV in the Dominican Republic. It compares the new method, which provides screening results and treatment on the same day, to the standard multi-visit process. The goal is to see if…

This study is testing whether a combination of chemotherapy and immunotherapy can effectively treat muscle-invasive bladder cancer, with the goal of allowing patients to keep their bladder instead of needing surgery to remove it. About 36 adults with localized bladder cancer will…

This study is testing if adding a low-dose cholesterol medication (atorvastatin) to standard CPAP therapy can reduce inflammation in the blood vessels of adults with sleep apnea. The goal is to see if this approach can lower the high risk of heart disease linked to sleep apnea. A…

This study is testing whether a drug called imatinib, already approved for leukemia, is safe for longer-term use in people with a rare lung disease called LAM. The trial will involve 20 women with LAM who will take either imatinib or a placebo for 6 months while researchers monit…

This study is testing a new dye called Gadopiclenol used during prostate MRI scans. The goal is to see if this dye makes aggressive prostate cancer show up more clearly, helping doctors better identify which areas need a biopsy. Researchers will compare the MRI results with biops…

This study is testing whether using a 3D printed model of a child's heart helps surgeons plan the placement of a life-support device called a VAD. It will compare surgery outcomes for children whose surgeons used a 3D model for planning versus those who used standard 2D scans. Th…

This study is testing a smartphone app designed to help new mothers monitor their physical and mental health symptoms after giving birth. The app provides guidance on when to seek emergency medical care for warning signs of serious pregnancy-related complications. The trial focus…

This study tests a church-based program where community health workers help adults get screened for colorectal cancer and adopt healthier habits to lower their risk of both cancer and heart disease. It focuses on English-speaking adults aged 45 and older who are not up-to-date wi…

This study aims to understand how to better help cisgender women and transgender individuals start and stay on daily medication that prevents HIV (called PrEP). Researchers will survey about 175 participants to learn their preferences for different prevention methods and support …

This study is testing if showing a unique picture symbol next to a newborn's name in the hospital computer system helps prevent doctors and nurses from accidentally ordering tests or treatments for the wrong baby. It involves parents choosing a symbol (like a rainbow or lion) for…

This study is testing whether a smartphone app combined with virtual peer support can help young men who have sex with men start and stay on HIV prevention medication (PrEP). The program delivers tailored information and connects participants with trained peers to overcome common…

This study is testing a 6-month virtual diet education program called PEDALL. It aims to prevent unhealthy weight gain in children and teens (ages 5-21) who are receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL). Participants will be randomly assigned to re…

This national study is testing whether a mobile phone app called MyPEEPS Mobile can help prevent new HIV infections. It will enroll 3,200 young men and non-binary individuals, aged 16-29, who are at high risk for HIV. Participants will use the app and be compared to a group recei…

This study is testing a new hospital safety program designed to prevent sepsis, a life-threatening infection that is a leading cause of death for mothers during and after childbirth. The program involves training staff, improving how sepsis is spotted and treated, and incorporati…

This study is testing a program called Free Time for Wellness (FT4W) to see if it helps low-income mothers in New York City get more physical activity. The program offers free weekly fitness classes, and some groups also get free childcare and peer support. Researchers will measu…

This study is testing whether training maternity doctors to provide more sensitive, trauma-informed care improves the mental health and well-being of pregnant women who survived childhood abuse. It will involve 60 first-time mothers in Argentina and measure their stress, depressi…

This study is testing if a flexible wound dressing called StrataCTX can help reduce the need for steroid creams in people with painful skin reactions. These reactions can be caused by skin lymphoma (CTCL) or by chemotherapy/immunotherapy treatments for other cancers. The main goa…

This study is testing whether eating pistachios can improve sleep quality for adults who don't sleep well. Researchers will compare pistachios to a similar snack without nuts to see if they make a difference. The goal is to find natural, food-based ways to help the millions of pe…

This study is testing whether a gentle electrical stimulation device worn on the ear can help reduce persistent symptoms like fatigue, pain, and brain fog in people who still feel sick after antibiotic treatment for Lyme disease. Researchers at Columbia University want to see if …

This study is testing if a device called VibraCool can help manage pain and reduce the need for opioid painkillers after ACL reconstruction surgery. Researchers will enroll 130 adults who have had this common knee surgery. They will compare pain levels and opioid use in people us…

This study is testing a wearable robotic glove called MyHand-SCI, designed to help people with spinal cord injuries in their neck regain hand function. Researchers will work with 40 participants to see if the device is easy to use and helpful for daily tasks. The goal is to gathe…

This study is testing a new group therapy called Motivation Skills Training (MST) for adults with schizophrenia or schizoaffective disorder. It aims to help participants understand and manage their motivation to improve daily functioning and reach personal goals. The therapy is c…

This study is testing whether using a robot to help surgeons perform a total knee replacement leads to better results than the standard manual technique. Researchers will enroll 86 adults with severe knee arthritis and randomly assign them to receive either the robot-assisted or …

This study is testing a special robotic neck brace designed to help children and young adults with severe cerebral palsy gain better control of their head and neck movements. Researchers will measure how well the brace works during training sessions over several months. The goal …

This study explores whether women receiving pregnancy or preconception care would be interested in adding hereditary cancer risk screening to their standard prenatal genetic tests. Researchers will offer 1,000 patients at Columbia University clinics the option to take both tests …

This study aims to understand how anxiety changes in the brain when people with alcohol use disorder stop drinking. Researchers will use MRI brain scans to compare people in recovery with healthy volunteers over time. The goal is to learn about the brain circuits involved, not to…

This study aims to understand the genetic causes behind severe allergies, asthma, eczema, and immune system disorders. Researchers will collect samples and medical information from up to 10,000 participants, including family members, who have or are suspected of having these inhe…

This study aims to find early signs that predict which people with a specific genetic lung disease (Alpha-1 PiMZ) are most likely to get worse. Researchers will follow 80 participants for three years, using CT scans and blood tests to track changes in their lungs. The goal is to …

This study aims to find the best way to stimulate the spinal cord in the neck to help restore hand and arm movement after a spinal cord injury. Researchers will test short-term electrical stimulation on 36 people who are already scheduled for neck surgery. The goal is to gather i…

This study is testing the safety of a new, non-invasive brain stimulation technique called transcranial interference stimulation (tIS) in healthy people. The long-term goal is to see if this method could one day help treat social and emotional difficulties in people with schizoph…

This study aims to understand a puzzle in early diabetes: why the liver might stop responding to insulin's signal to lower blood sugar but keep making fat. Researchers will give a single dose of a drug called alpelisib or a placebo to healthy adults and adults at risk for type 2 …

This study aims to develop a new technology platform called CAMERA that uses multiple sensors to measure brain activity, body signals, and behavior. Researchers want to see if they can use this data to predict a person's anxiety levels and memory performance throughout the day. T…

This study aims to better understand how specific genetic changes affect people's health and development over time. Researchers will observe and collect information from up to 1,000 individuals who have a confirmed genetic variant linked to conditions like autism, developmental d…

This study is testing whether Spanish-language educational videos can help Latinx patients better understand their radiation therapy for breast or prostate cancer. Researchers want to see if these videos improve treatment adherence and make patients more open to joining future ca…

This small, early-stage study aims to understand the role of high insulin levels in people with obesity. Researchers will give participants a drug called diazoxide for four days to temporarily lower their insulin production. They will measure daily blood sugar and insulin levels …

This study aims to understand why ultra-processed foods might cause weight gain by measuring how many calories the gut absorbs from them. Researchers will compare two diets—one high and one low in ultra-processed foods—in 20 adults with obesity. They will analyze stool samples to…

This study aims to observe and understand how hypoparathyroidism affects the body over three years. Researchers will follow 106 adults with the condition to track potential damage to organs like the kidneys, brain, and blood vessels. The goal is to gather detailed information to …

This study aims to develop better ways to measure how diseases like Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA) progress over time. Researchers will have 106 children wear special 'smart' insoles in their shoes to track their walking patterns both in a lab…

This study is creating a national registry and sample bank for people with mitochondrial disorders—rare genetic diseases that affect the body's energy production. By collecting health information and tissue samples from up to 1,000 participants, researchers aim to build a shared …

This study aims to understand why children with a rare condition called ROHHAD syndrome develop extremely rapid and severe obesity. Researchers will study 12 children with ROHHAD and their close family members to look for differences in their cells' genetic activity and metabolis…

This study is testing whether a detailed genetic test can safely and effectively expand the list of rare diseases screened for in newborns. It will enroll 100,000 babies to see if finding these conditions early, even before symptoms appear, leads to better health outcomes. Parent…

This study follows 800 people who recovered from COVID-19 for two years to understand how long the virus can stay in different parts of the body and what long-term health problems might develop. Researchers collect blood, saliva, stool, and other samples up to 12 times to track v…

This study is measuring how an 8-month neuroscience apprenticeship program affects high school students' confidence in science and interest in science careers. Researchers will track 180 students from Upper Manhattan and the South Bronx as they learn lab skills and work with ment…

This study aims to understand how a mother's stress and life experiences might affect tiny energy centers in her cells (mitochondria) and inflammation, potentially increasing the risk of preterm birth. Researchers will follow 180 pregnant women to see if different stress profiles…

This study aims to find the most effective and practical way to break up long periods of sitting. Researchers will test different combinations of how often and for how long healthy adults should take short walking breaks during an 8-hour day. The goal is to discover the smallest …

This study aims to understand how vision declines over time in people with a specific genetic form of retinitis pigmentosa (CNGB1-RP). Researchers will follow 20 participants for three years, using detailed eye scans and vision tests to track disease progression. The goal is to g…

This study aims to understand if the brains of adults with cerebral palsy change over time, which might explain why some people experience worsening function as they age. Researchers will analyze existing and new MRI brain scans from 30 adults with cerebral palsy across the U.S. …

This study aims to better understand how people with Spinal Muscular Atrophy experience physical fatigue during their daily activities while receiving nusinersen treatment. Researchers will follow 45 adolescents and adults who have been on stable nusinersen dosing for at least 6 …

This study aims to understand the genetic causes of severe obesity that starts very early in childhood. Researchers will enroll 500 children and adults who were severely obese before age 6, ask health questions, perform a brief exam, and collect saliva or blood for genetic testin…

This study aims to understand how ALS begins and progresses in people who carry a gene for the disease but don't yet have symptoms. Researchers will follow 300 healthy family members of ALS patients over time, offering genetic counseling and testing. The goal is to gather informa…

This is a small, early-stage study to test a new procedure for measuring how the hormone insulin works in the body. Researchers want to understand how much insulin is actually needed to keep blood sugar normal. They will test this new method, called a Graded Insulin Suppression T…

This study aims to learn more about a rare genetic condition caused by a specific mitochondrial DNA mutation (m.3243A>G). Researchers will observe 300 participants, including people who carry the mutation and their family members, over time to understand the wide range of symptom…

This study aims to discover which genes might make someone more likely to be born with a congenital diaphragmatic hernia (CDH), a serious birth defect. Researchers will collect DNA samples from 3000 people, including those with CDH and their family members, to look for genetic pa…

This study aims to understand how loneliness changes the way our brains think about ourselves and other people. Researchers will use MRI brain scans on 248 participants while they reflect on their social connections. The goal is to learn how the brain organizes feelings of closen…

This study aims to better understand how neuromuscular diseases affect daily life by measuring physical activity. Participants, including both people with these diseases and healthy volunteers, will wear a small, button-like monitor on their thigh for one week every six months ov…

This study aims to find people at risk for a serious heart condition called ATTR amyloidosis by checking tissue saved from their past lower back surgeries. Researchers will test the tissue for a specific protein and invite some participants for heart tests to see if the condition…

This study is creating a collection of tissue and blood samples from people with cutaneous T-cell lymphoma (CTCL) and from healthy volunteers. The goal is to store these samples for future research, not to test a treatment. Researchers hope this 'biobank' will help scientists bet…

This study aims to understand how structural racism might increase the risk of substance use in adolescents. Researchers will study 72 Puerto Rican teens in New York and Puerto Rico, looking at how factors like neighborhood income and education relate to their brain structure, de…

This study aims to understand how a mother's stress during pregnancy affects her baby's brain and behavioral development. Researchers are comparing IVF pregnancies using donor eggs (where mother and baby don't share genes) with regular IVF pregnancies to separate environmental ef…

This study aims to understand if eating meals at unusual times, like late at night, affects your body's ability to manage weight and energy. Researchers will compare what happens when people eat soon after waking versus several hours later, while keeping sleep schedules the same.…