New study aims to predict MS risk using genes and environment

NCT ID NCT01353547

Recruiting now Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is trying to figure out what makes someone more likely to develop multiple sclerosis (MS). Researchers are looking at a mix of genetic, environmental, and immune factors in 5,000 people in the US, including relatives of MS patients and others at higher risk. The goal is to create a risk score that could one day help with early detection or prevention.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a risk score that helps identify people at higher risk for MS, potentially enabling earlier monitoring or prevention strategies.
What could go wrong: This is an observational study, not a treatment trial. It may not produce a usable risk algorithm, and results may not apply to the general population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS

Contacts and locations

Locations

Brigham and Women's Hospital
TERMINATED

Boston, Massachusetts, 02115, United States
Columbia University Irving Center
RECRUITING

New York, New York, 10032, United States
Massachusetts General Hospital
TERMINATED

Boston, Massachusetts, 02114, United States
National Institute of Neurological Disorders and Stroke
RECRUITING

Bethesda, Maryland, 15213, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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