Columbia University

This study looks at two ways to repair a torn ACL: standard surgery using a piece of the patient's own tendon, or the same surgery plus an extra internal brace to strengthen the repair. Researchers want to see if the brace helps people return to sports faster and reduces the chan…

This study compares two blood thinners—apixaban and warfarin—in people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents serious problems like stroke, blood clots, and major bleeding. About 460 adults who have had the pum…

This study looks at how a device called Barostim affects heart function and symptoms in adults with heart failure and reduced pumping ability. About 58 people will get the device implanted and adjusted. The goal is to see if it improves blood flow and exercise capacity.

This early-stage study tests the safety of a drug called EMPAVELI in 20 adults who had a stroke from a large blood clot and already had it removed. The drug is given through a pump shortly after the procedure and again at 24 and 48 hours to reduce swelling and inflammation when b…

This study compares surgery (MPFL reconstruction) to a structured rehab program for people who have dislocated their kneecap for the first time. Researchers want to see which approach better prevents future dislocations and improves knee function and symptoms. The study will foll…

This study compares two common treatments for people who have dislocated their shoulder for the first time: surgery (arthroscopic Bankart repair) versus physical therapy. Researchers want to see which approach leads to better shoulder function, less pain, and fewer repeat disloca…

This study will give HEPA air cleaners to 55 children (ages 7-18) with asthma living in low-income housing in East Harlem, NYC. Researchers will measure indoor air pollution and track asthma symptoms, lung function, and emergency visits over a year. The goal is to see if a simple…

This study will compare three methods for checking tooth vitality (whether the nerve is alive): laser Doppler flowmetry, electric pulp testing, and cold testing. About 150 people who need root canal treatment will receive all three tests. The goal is to see which test is most acc…

This study compares ketamine to morphine for treating sudden, severe pain in children visiting the emergency department. About 1,010 children with belly pain or a broken arm or leg will receive one of the two medicines. The goal is to see if ketamine works just as well but causes…

This study will test whether a culturally-based live music intervention can lower stress and reduce the risk of preterm birth in pregnant Black women. Researchers will compare the music group to a control group that only receives verbal support. The goal is to see if music can im…

This study tests whether giving children (ages 5-17) a breathing machine called BPAP early in the emergency room can help them recover faster from severe asthma attacks. About 36 kids will either get standard asthma care alone or standard care plus BPAP. The goal is to see if thi…

This study tests adding two drugs, dexmedetomidine or clonidine, to standard spinal anesthesia for women having a C-section. The goal is to reduce uncomfortable pulling, tugging, or pressure during surgery and improve pain relief after. About 150 pregnant women will take part, an…

This study looks at how tirzepatide, a diabetes drug, helps people with obesity and a type of heart failure called HFpEF. Researchers will measure blood volume and body fat in 50 patients over 15 months to understand how the drug works. The goal is to find out if tirzepatide redu…

This study will screen over 7,000 adults aged 40 and older living in affordable housing in New York City for undiagnosed or uncontrolled high blood pressure and glaucoma. Participants will receive free screenings and be referred to follow-up care. The goal is to see if a virtual …

This study tests whether digital messages created by sex trafficking survivors can encourage other survivors in New York City to get tested for HIV, STIs, and hepatitis C, and to use overdose prevention kits. About 368 survivors will be randomly assigned to see either survivor-cr…

This study will test whether using brain-wave (EEG) monitoring to guide pain medicine during surgery can help prevent delirium—sudden confusion—in older adults after the operation. Researchers plan to enroll 600 people aged 60 and older who are having non-cardiac, non-head/neck s…

This study looks at how changing insulin levels affects the liver's production of sugar and fat in people with insulin resistance, prediabetes, and fatty liver disease. Participants will undergo two procedures where insulin is either kept at a high level or lowered by half, and r…