Scientists probe insulin needs in obesity and health

NCT ID NCT06592261

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medications through an IV to temporarily stop their own insulin production, then receive insulin at two levels while blood sugar is monitored closely. The goal is to measure how much insulin the body actually needs to keep blood sugar normal.

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Conditions

The condition(s) this trial relates to.

hyperinsulinism Insulin Resistance Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact