Scientists probe insulin needs in obesity and health

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medications through an IV to temporarily stop their own insulin production, then receive insulin at two levels while blood sugar is monitored closely. The goal is to measure how much insulin the body actually needs to keep blood sugar normal.