SCHIZOAFFECTIVE DISORDER

This 12-week study is for people who completed a previous trial of the ketogenic diet for first-episode bipolar disorder. Researchers want to see if the diet can improve symptoms like depression, mania, and psychosis, as well as brain energy metabolism and insulin resistance. Abo…

This study looks at whether adding topiramate (a seizure medication) to clozapine can help with weight loss and improve symptoms in people with treatment-resistant schizophrenia or schizoaffective disorder. About 50 overweight or obese adults aged 17-59 who are already on clozapi…

This study tests whether a combination of dasatinib and quercetin, two drugs that clear out aging cells, can safely slow down accelerated aging in older adults with treatment-resistant depression or schizophrenia. Forty participants aged 50 and older will take the drugs and be mo…

This study tests whether offering financial rewards can help people with schizophrenia, bipolar disorder, or substance use disorder stick to their long-acting injectable medication after being forced into the hospital. About 1,000 participants will be randomly assigned to receive…

This study tests whether a more targeted form of transcranial magnetic stimulation (TMS) can help people with schizophrenia whose symptoms don't improve with medication. The treatment uses each patient's own brain wave frequency (alpha rhythm) and MRI scans to precisely stimulate…

This study tests whether an accelerated schedule of transcranial magnetic stimulation (TMS) is safe and effective for treating symptoms of psychotic disorders like schizophrenia. About 20 adults aged 18-65 with schizophrenia, schizoaffective disorder, or at high risk for psychosi…

This study tests a group version of the Feeling Safe Programme, a type of cognitive behavioral therapy for people with schizophrenia or schizoaffective disorder. The goal is to reduce distressing symptoms like paranoia and hallucinations and improve quality of life. Fifty partici…

This study aimed to see if a dissolvable film placed under the tongue could quickly calm agitation in people with bipolar disorder or schizophrenia who come to the emergency room. The drug, BXCL501, is already approved for this use, but the study wanted to test it in the ER setti…

This study tests whether a type of brain stimulation called cTBS can improve thinking and memory in people with schizophrenia. Forty participants will receive targeted stimulation to a brain network linked to daydreaming and self-focus. The goal is to see if this changes brain ac…

This study looks at how gut bacteria change when young people (ages 12-35) with psychosis start taking antipsychotic medication. Researchers want to see if these changes are linked to weight gain and other metabolic problems. Participants provide stool and blood samples over 12 w…

This study tests a brain stimulation technique called paired associative stimulation (PAS) using transcranial magnetic stimulation (TMS) in 72 adults with schizophrenia. The goal is to see if daily sessions over two weeks can improve working memory, as measured by a letter-matchi…

This study uses a noninvasive brain stimulation technique called TMS, combined with brain scans, to understand working memory problems in people with early psychosis. Twenty participants will receive both active and placebo TMS to see how it affects brain activity and memory perf…

This study is collecting DNA, brain scans, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. The goal is to better understand the physical and genetic factors behind these conditions, whi…

This study looks at whether brain wave patterns recorded during and after electroconvulsive therapy (ECT) can predict how much depression symptoms improve. About 31 adults with treatment-resistant depression will have their brain activity measured with a wearable EEG device. The …

This study was designed to track stress in real time by measuring things like heart rate, sweat, and temperature, along with how people feel. It planned to include both healthy volunteers and people with psychiatric disorders to find better ways to diagnose stress-related problem…

This study tests whether adding executive function training to cognitive-behavioral social skills training helps older adults (60+) with schizophrenia learn skills better and improve daily living. About 49 participants will take part. The goal is to see if the combined approach i…

This study looks at whether adding cognitive remediation (computer-based brain exercises with group coaching) to standard care helps young people with early psychosis function better in daily life. About 117 participants from nine OnTrackNY programs will either get usual care or …