Can magnetic pulses unlock memory secrets in early psychosis?

NCT ID NCT05857137

Ongoing Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses a noninvasive brain stimulation technique called TMS, combined with brain scans, to understand working memory problems in people with early psychosis. Twenty participants will receive both active and placebo TMS to see how it affects brain activity and memory performance. The goal is to learn about the brain mechanisms involved, not to provide a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS)
What this could lead to: If successful, this could help identify brain targets for future treatments to improve memory in early psychosis.
What could go wrong: This is a very small, early-stage study with only 20 participants. It is designed to understand brain function, not to test a treatment, so direct benefits are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder Cognitive Dysfunction delusional disorder psychotic disorder Psychotic Disorders schizoaffective disorder schizophrenia schizophreniform disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSYCHOSIS

Contacts and locations

Locations

Martinos Center for Biomedical Imaging

Charlestown, Massachusetts, 02129, United States

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